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Publication Metadata only A nation-wide study determining psychosocial care skill perceptions of Turkish nurses working with cancer patients(Wiley, 2018) Yildirim, Nazmiye Kocaman; Inci, Figen; Hicdurmaz, Duygu; Fernandez, Ritin Santiago; Ozdemir, Sevgul; Ince, Aysegul; Yildirim, Yeter; N/A; Güner, Perihan; Faculty Member; School of Nursing; 101859N/APublication Metadata only A nation-wide study of Turkish oncology nurses' perceptions towards providing care for cancer patients(Wiley, 2018) Inci, Figen; Hicdurmaz, Duygu; Yildirim, Nazmiye Kocaman; Fernandez, Ritin Santiago; Ozdemir, Sevgul; Ince, Aysegul; Yildirim, Yeter; N/A; Güner, Perihan; Faculty Member; School of Nursing; 101859N/APublication Metadata only A platinum-blue complex exerts its cytotoxic activity via dna damage and induces apoptosis in cancer cells(Elsevier, 2016) Adiguzel, Z.; Ozalp-Yaman, S.; Celik, G.; Salem, S.; Cetin, Y. C.; Arda, N.; Acilan, C.; N/A; Önder, Tuğba Bağcı; Faculty Member; School of Medicine; 184359N/APublication Metadata only A primary extended cytoreductive surgery for ovarian cancer: total abdominal hysterectomy and bilateral salpingo-oophorectomy, total omentectomy, total peritonectomy, bilateral diaphragm stripping, cholecystectomy, total colectomy, splenectomy, bilateral pelvic-paraaortic lymphadenectomy, dissection of porta hepatis, liver metastasectomy, and bilateral cardiophrenic lymphadenectomy(Bmj Publishing Group, 2019) Giray, B.; Kumcular, T.; Arvas, M.; N/A; N/A; N/A; N/A; Taşkıran, Çağatay; Vatansever, Doğan; Mısırlıoğlu, Selim; Balık, Emre; Faculty Member; Faculty Member; Faculty Member; N/A; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; 134190; 193687; N/A; N/A; 18758Introduction/Background: Ovarian cancer is the leading cause of death among gynecological malignancies. Primary cytoreduction for ovarian cancer is associated with significantly improved survival. We aimed to present a primary extended cytoreduction performed in this video. Methodology: A 37 years-old woman was admitted with abdominal swelling and pelvic pain. Pelvic examination revealed out ascites and bilateral adnexal masses. MRI showed 11-cm right adnexal mass, 7-cm left adnexal mass, omental cakes, disseminated peritoneal implants, liver metastases, and enlarged lymph nodes in the right obturator fossa. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, total omentectomy, total peritonectomy, bilateral diaphragmatic stripping, total colectomy, splenectomy, bilateral pelvic-paraaortic lymphadenectomy, cholecystectomy, dissection of the porta hepatis, liver metastasectomy, and transabdominal cardiophrenic lymph node dissection were performed as a part of maximal primarily cytoreduction. Results: We did not encounter any grade 3 or 4 adverse event in post-operative period. Conclusion: Primary cytoreduction for ovarian cancer with no residual disease is a major impact on survival. The management of this condition should be performed with expert multidisciplinary teams in gynecological oncology.Publication Metadata only A systematic review of the efficacy and toxicity of brachytherapy boost combined with external beam radiotherapy for nonmetastatic prostate cancer(Elsevier, 2023) Slevin, F; Zattoni, F; Checcucci, E; Cumberbatch, MGK; Nacchia, A; Cornford, P; Briers, E; De Meerleer, G; De Santis, M; Eberli, D; Gandaglia, G; Gillessen, S; Grivas, N; Liew, M; Linares Espinós, EE; Oldenburg, J; Oprea-Lager, DE; Ploussard, G; Rouvière, O; Schoots, IG; Smith, EJ; Stranne, J; Smith, CT; Van Den Bergh, RCN; Van Oort, IM; Wiegel, T; Yuan, CY; Van den Broeck, T; Henry, AM; Tilki, Derya; School of Medicine; Koç University HospitalContext: The optimum use of brachytherapy (BT) combined with external beam radiotherapy (EBRT) for localised/locally advanced prostate cancer (PCa) remains uncertain. Objective: To perform a systematic review to determine the benefits and harms of EBRT-BT. Evidence Acquisition: Ovid MEDLINE, Embase, and EBM Reviews-Cochrane Central Register of Controlled Trials databases were systematically searched for studies published between January 1, 2000 and June 7, 2022, according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Eligible studies compared low- or high-dose-rate EBRT-BT against EBRT ± androgen deprivation therapy (ADT) and/or radical prostatectomy (RP) ± postoperative radiotherapy (RP ± EBRT). The main outcomes were biochemical progression-free survival (bPFS), severe late genitourinary (GU)/gastrointestinal toxicity, metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS), at/beyond 5 yr. Risk of bias was assessed and confounding assessment was performed. A meta-analysis was performed for randomised controlled trials (RCTs). Evidence Synthesis: Seventy-three studies were included (two RCTs, seven prospective studies, and 64 retrospective studies). Most studies included participants with intermediate-or high-risk PCa. Most studies, including both RCTs, used ADT with EBRT-BT. Generally, EBRT-BT was associated with improved bPFS compared with EBRT, but similar MFS, CSS, and OS. A meta-analysis of the two RCTs showed superior bPFS with EBRT-BT (estimated fixed-effect hazard ratio [HR] 0.54 [95% confidence interval {CI} 0.40-0.72], p < 0.001), with absolute improvements in bPFS at 5-6 yr of 4.9-16%. However, no difference was seen for MFS (HR 0.84 [95% CI 0.53-1.28], p = 0.4) or OS (HR 0.87 [95% CI 0.63-1.19], p = 0.4). Fewer studies examined RP ± EBRT. There is an increased risk of severe late GU toxicity, especially with low-dose-rate EBRT-BT, with some evidence of increased prevalence of severe GU toxicity at 5-6 yr of 6.4-7% across the two RCTs. Conclusions: EBRT-BT can be considered for unfavourable intermediate/high-risk localised/locally advanced PCa in patients with good urinary function, although the strength of this recommendation based on the European Association of Urology guideline methodology is weak given that it is based on improvements in biochemical control. Patient Summary: We found good evidence that radiotherapy combined with brachytherapy keeps prostate cancer controlled for longer, but it could lead to worse urinary side effects than radiotherapy without brachytherapy, and its impact on cancer spread and patient survival is less clear.Publication Metadata only Advanced practice pediatric oncology nursing as imagined or in place in four lower- and upper-middle-income countries(Elsevier Science Inc, 2024) Samba, Vera Larfi; Diaz, Dorian René Navarro; Punjwani, Rehana; Challinor, Julia; Semerci, Remziye; School of NursingObjectives: The implementation of pediatric oncology advanced practice nurse (s) roles in low- and middleincome countries (LMICs) presents opportunities and challenges. The authors explore the implications of pediatric oncology advanced practice nursing roles in Pakistan, Cameroon, Turkey, and Mexico. Potential bene fits and drawbacks of advanced practice nursing roles, impacts on nursing care, and strategies for advanced practice nursing role development in LMIC settings are considered. Methods: Information from scholarly articles, policy documents, and four LMIC pediatric oncology nurse expert perspectives on existing and imagined advanced practice nursing roles in pediatric oncology in LMIC were synthesized. Results: Current literature and policies point to efforts across LMICs to establish a wide variety of advanced nursing practices, not necessarily aligned with internationally accepted advanced practice nursing standards of practice or education. The LMIC nurses describe a wide range of national general nurse education and government advanced practice nurse recognition/licensing. Challenges to achieving or strengthening advanced practice nursing roles include, for example, healthcare professional resistance, government unwillingness to recognize/license advanced practice nurses, and lack of advanced practice nursing faculty. To promote a pediatric oncology advanced practice nursing role in LMICs requires navigating the national nursing scope of practice and nursing culture. Conclusion: The strategic introduction of pediatric oncology advanced practice nursing roles in LMICs has the potential to signi ficantly enhance patient care by, for example, addressing healthcare workforce shortages and facilitating timely care delivery. However, challenges related to role complexity, resistance from traditional healthcare structures, and role overlap must be considered. Tailoring these roles to local contexts and fostering stakeholder collaboration are essential for successful implementation. Implications for Nursing Practice: The adoption of advanced practice nursing roles can lead to improved quality of care for pediatric oncology patients and their families in LMICs, where cancer care is challenging. The positive impact of pediatric oncology advanced practice nurses on patient outcomes and healthcare delivery cannot be discounted but must align with local nursing and healthcare culture and expectations. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Publication Metadata only Altered inflammatory and death pathways in head and neck cell lines model genomic and expression signatures identified in the cancer genome Atlas(American Association for Cancer Research, 2015) Yang, Xinping; Cheng, Hui; Saleh, Anthony; Cornelius, Shaleeka; Nussinov, Ruth; Van Weas, Carter; Chen, Zhong; Department of Computer Engineering; Department of Chemical and Biological Engineering; Maiorov, Emine Güven; Keskin, Özlem; Gürsoy, Attila; PhD Student; Faculty Member; Faculty Member; Department of Computer Engineering; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; N/A; 26605; 8745Publication Metadata only An exploratory study of positive life changes in Turkish women diagnosed with breast cancer(Elsevier Sci Ltd, 2010) N/A; N/A; Güner, Perihan; Faculty Member; School of Nursing; 101859Purpose: The present study explored the prevalence of positive changes in Turkish women with breast cancer and the possible relationships between these changes and patient variables such as socio-demographic and illness-related information. It also explored the nature of positive life changes reported by Turkish women with breast cancer. Methods and sample: The study was conducted at Hacettepe University Oncology Hospital in Ankara. Participants were 84 women with breast cancer and open-ended questionnaires eliciting patient narratives were primarily used to collect the data. Socio-demographic and illness characteristics, as well as any positive changes in the participants' life after the breast cancer diagnosis was also collected. For the participants who indicated positive changes a further open-ended question was asked: "Could you write down the positive changes that occurred in your life after being diagnosed with breast cancer?". Content analysis was used to analyze the qualitative data gathered from the participants who mentioned a positive change in their life following the breast cancer diagnosis. Results: Positive life changes were reported by 50% (n = 42) of the women and these changes were found to increase only with an increase in the patients' educational level. Qualitative analysis of the data indicated four main themes of positive changes: self-perception, empowerment, greater appreciation of life, and changes in interpersonal relations. Conclusion: If nurses are aware of positive changes following the illness, they can help their patients to understand, adapt better and cope with their illness.Publication Metadata only Androgen receptor binding sites are highly mutated in prostate cancer(American Association for Cancer Research (AACR), 2018) N/A; Department of Industrial Engineering; Department of Computer Engineering; Department of Chemical and Biological Engineering; N/A; Morova, Tunç; Gönen, Mehmet; Gürsoy, Attila; Keskin, Özlem; Lack, Nathan Alan; N/A; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Department of Industrial Engineering; Department of Computer Engineering; Department of Chemical and Biological Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; College of Engineering; College of Engineering; College of Engineering; School of Medicine; N/A; 237468; 8745; 26605; 120842Publication Metadata only Aso visual abstract: in-hospital venous thromboembolism and pulmonary embolism after major urological cancer surgery(Springer, 2023) Garcia, Cristina Cano; Tappero, Stefano; Piccinelli, Mattia Luca; Barletta, Francesco; Incesu, Reha-Baris; Morra, Simone; Scheipner, Lukas; Baudo, Andrea; Tian, Zhe; Hoeh, Benedikt; Chierigo, Francesco; Sorce, Gabriele; Saad, Fred; Shariat, Shahrokh F.; Carmignani, Luca; Ahyai, Sascha; Longo, Nicola; Briganti, Alberto; De Cobell, Ottavio; Dell'Oglio, Paolo; Mandel, Philipp; Terrone, Carlo; Chun, Felix K. H.; Karakiewicz, Pierre I.; Tilki, Derya; School of Medicine; Koç University HospitalN/A