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Subject: search.filters.subject.DNA

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Now showing 1 - 5 of 5
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    A coarse grained model of DNA and supercoiling dynamics
    (Koç University, 2013) Öztürk, Murat; Sayar, Mehmet; 0000-0003-0553-0353; Koç University Graduate School of Sciences and Engineering; Computational Sciences and Engineering; 109820
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    Comprehensive analysis of circulating viral DNA in maternal plasma at population-scale using low-pass whole-genome sequencing
    (Academic Press Inc., 2023) Eldem, V.; Kuralay, S.C.; Özdoğan, G.; Özçelik, G.H.; Aydın, D.; Çakmak, G.; Gürler, M.Ö.; Çay, S.B.; Çınar, Y.U.; Dikmen, F.; Yusuf, I.; Obut, O.; Zararsız, G.E.; Edizadeh, M.; Zararsız, G.; Akdeniz, E.; Özgür, H.; Tekin, I.M.; N/A; Kayalar, Özgecan; Researcher; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A
    As the most readily adopted molecular screening test, low-pass WGS of maternal plasma cell-free DNA for aneuploidy detection generates a vast amount of genomic data. This large-scale method also allows for high-throughput virome screening. NIPT sequencing data, yielding 6.57 terabases of data from 187.8 billion reads, from 12,951 pregnant Turkish women was used to investigate the prevalence and abundance of viral DNA in plasma. Among the 22 virus sequences identified in 12% of participants were human papillomavirus, herpesvirus, betaherpesvirus and anellovirus. We observed a unique pattern of circulating viral DNA with a high prevalence of papillomaviruses. The prevalence of herpesviruses/anellovirus was similar among Turkish, European and Dutch populations. Hepatitis B prevalence was remarkably low in Dutch, European and Turkish populations, but higher in China. WGS data revealed that herpesvirus/anelloviruses are naturally found in European populations. This represents the first comprehensive research on the plasma virome of pregnant Turkish women.
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    Elastic light scattering and optoelectronic response of spherical silicon microresonators
    (Koç University, 2014) Gökay, Ulaş Sabahattin; Serpengüzel, Ali; 0000-0002-0676-8817; Koç University Graduate School of Sciences and Engineering; Physics; 27855
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    Genome-wide mapping of nucleotide excision repair in arabidopsis root and shoot & the fate of LYM1/2 proteins during nodulation in medicago truncatula
    (Koç University, 2022) Erdoğan, Duğçar Ebrar; Öztaş, Onur; 0000-0002-2185-6532; Koç University Graduate School of Sciences and Engineering; Molecular Biology and Genetics; 330370
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    Investigating the role of nuclear receptor enhancers on gene transcription
    (Koç University, 2022) Altıntaş, Umut Berkay; Lack, Nathan Alan; 0000-0001-7399-5844; Koç University Graduate School of Sciences and Engineering; Computational Sciences and Engineering; 120842