Researcher:
Balcan, Mehmet Baran

Profile Picture
ORCID

Job Title

Faculty Member

First Name

Mehmet Baran

Last Name

Balcan

Name

Name Variants

Balcan, Mehmet Baran

Email Address

Birth Date

Filters

20224

Advanced Search

Filter by

Settings

Researcher Of Publications: search.filters.isAuthorOfPublication.43e55389-4672-4e3b-a948-e7691b00e59e

Search Results

Now showing 1 - 4 of 4
  • Placeholder
    PublicationMetadata only
    Associates of neutrophil/lymphocyte ratio in patients with COVID 19 infection: a single center experience
    (European Respiratory Society (ERS), 2022) Turan, B.; Baysal, E.; Omur, C.; Abdurrahman, Y.; Cinar, C.; Kocakaya, D.; Yildizeli, S. Olgun; Eryuksel, E.; Karakurt, S.; N/A; Balcan, Mehmet Baran; Faculty Member; School of Medicine; Koç University Hospital; 172783
    Aims and objective: We addressed the determinants and of the factors associated with neutrophil lymphocyte (N/L) ratio in patients with COVID 19 infection and its associates with mortality. Methods: 163 participants with COVID 19 infection who were treated in the clinic and ICU were evaluated retrospectively. Demographics, laboratory findings, hospitalization duration, baseline Who and Charlson scores and mortality were assessed. Results: 163 participants 44.8 % women were evaluated retrospectively. Mean age of the patients was 55.8 ± 16.8. Mortality observed in 14.1 % of the participants. There were significant difference between the groups regarding the laboratory findings, hospitalization duration, comorbidity indexes and admission to ICU in deceased group when compared to survivors. There was a significant difference between the patients who were admitted to intensive care unit (ICU) and who were not regarding the neutrophil lymphocyte (N/L) ratio (9.56 ± 1.68 & 3.47 ± 0.31; p=0.001). there was also significant difference between the adults who died and survived (9.72 ± 1.87 & 4.03 ± 0.44; p=0.007). There were significant associations between N/L levels and CRP (OR = 0.441, 95 % CI = 0.019 – 0.058; p = <0.001) D-dimer (OR=0.566, 95 % CI = 0.821 – 1.541; p<0.001) as well as Who score at baseline (OR = 0.309, 95 % CI =0.990 – 3.604; p<0.001). Conclusion: Neutrophil/lymphocyte ratio is associated with CRP, D-dimer and Who score at baseline but not with the mortality.
  • Placeholder
    PublicationMetadata only
    Association of REM predominant obstructive sleep apnoea severity with depression and quality of life in adults with coronary artery disease in the RICCADSA cohort
    (European Respiratory Society (ERS), 2022) N/A; Balcan, Mehmet Baran; Çelik, Yeliz; Peker, Yüksel; Faculty Member; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; Koç University Hospital; N/A; N/A; 172783; N/A; 234103
    Background: Obstructive sleep apnoea (OSA) is common in adults with coronary artery disease (CAD). OSA that occurs predominantly during REM-sleep has been identified as a specific OSA phenotype. Aims and Objective: We addressed whether or not there is a dose-response relationship between REM-predominant OSA and functional outcomes, mood and quality of life in a CAD cohort. Methods: The current study was a secondary analysis of the RICCADSA trial. In all, 286 OSA patients with total sleep time ≥240 min, and REM sleep ≥30 min, were included. REM- predominant OSA was defined as REM-apnoea hypopnoea index (AHI) /non-REM (NREM)-AHI ≥2. Multiple regression analyzes were used to address the association of REM-AHI with the Functional Outcome of Sleep Questionnaire (FOSQ), Zung Self-rated Depression Scale (SDS) and Anxiety Scale (SAS) as well as Short Form-36 Health Survey (SF- 36) scores. Results: In all, 73 (25.5%) had REM-predominant OSA. There was a significant dose-response relationship between Zung SDS scores and REM-AHI. No correlation was found between REM-AHI and FOSQ as well as Zung SAS scores. SF-36 subdomains vitality, mental health, and mental composite score (MCS) were inversely correlated with REM-AHI. In the multivariate models, only the inverse relationship between REM-AHI and MCS remained significant after adjustment for age, body-mass-index, and sex (β-coefficient -2.20, %95 CI [-0.56, -0.03] ; p=0.03). Conclusions: Our results suggest an independent inverse dose-response relationship between REM-AHI and mental composite score. The relationship between REM-AHI and SDS, vitality and mental health were dependent on female sex.
  • Thumbnail Image
    PublicationOpen Access
    REM-predominant obstructive sleep apnea in patients with coronary artery disease
    (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Newitt, Jennifer; Strollo, Patrick J., Jr.; Balcan, Mehmet Baran; Çelik, Yeliz; Peker, Yüksel; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; N/A; N/A; 234103
    Obstructive sleep apnea (OSA) is common in adults with coronary artery disease (CAD). OSA that occurs predominantly during rapid-eye movement (REM) sleep has been identified as a specific phenotype (REM-predominant OSA) in sleep clinic cohorts. We aimed to examine the association of REM-predominant OSA with excessive sleepiness, functional outcomes, mood, and quality of life in a CAD cohort, of whom 286 OSA patients with total sleep time >= 240 min, and REM sleep >= 30 min, were included. REM-predominant OSA was defined as a REM-apnea-hypopnea-index (AHI) /non-REM (NREM) AHI >= 2. In all, 73 (25.5%) had REM-predominant OSA. They were more likely to be female (26.0% vs. 9.9%; p = 0.001), and more obese (42.5% vs. 24.4%; p = 0.003) but had less severe OSA in terms of AHI (median 22.6/h vs. 36.6/h; p < 0.001) compared to the patients with non-stage specific OSA. In adjusted logistic regression models, female sex (odds ratio [OR] 4.64, 95% confidence interval [CI] 1.85-11.64), body-mass-index (BMI; OR 1.17; 95% CI 1.07-1.28) and AHI (OR 0.93, 95% CI 0.91-0.95) were associated with REM-predominant OSA. In univariate linear regression models, there was a dose-response relationship between REM-AHI and Zung Self-rated Depression Scale but not excessive sleepiness, functional outcomes, and anxiety scores. Among the Short Form-36 subdomains, Vitality, Mental Health, and Mental Component Summary (MCS) scores were inversely correlated with REM-AHI. In multivariate linear models, only MCS remained significantly associated with REM-AHI after adjustment for age, BMI, and sex (beta-coefficient -2.20, %95 CI [-0.56, -0.03]; p = 0.028). To conclude, female sex and BMI were related to REM-predominant OSA in this revascularized cohort. MCS was inversely associated with REM-AHI in the multivariate model.
  • Thumbnail Image
    PublicationOpen Access
    CPAP intervention as an add-on treatment to lipid-lowering medication in coronary artery disease patients with obstructive sleep apnea in the RICCADSA trial
    (Multidisciplinary Digital Publishing Institute (MDPI), 2022) Çelik, Yeliz; Balcan, Mehmet Baran; Peker, Yüksel; Researcher; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; N/A; N/A; 234103
    Dyslipidaemia is a well-known risk factor for coronary artery disease (CAD), and reducing lipid levels is essential for secondary prevention in management of these high-risk individuals. Dyslip-idaemia is common also in patients with obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) is the first line treatment of OSA. However, evidence of a possible lipid-lowering effect of CPAP in CAD patients with OSA is scarce. We addressed the effect of CPAP as an add-on treatment to lipid-lowering medication in a CAD cohort with concomitant OSA. This study was a secondary analysis of the RICCADSA trial (Trial Registry: ClinicalTrials.gov; No: NCT 00519597), that was conducted in Sweden between 2005 and 2013. In total, 244 revascularized CAD patients with nonsleepy OSA (apnea–hypopnea index ? 15/h, Epworth Sleepiness Scale score < 10) were randomly assigned to CPAP or no-CPAP. Circulating triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels (all in mg/dL) were measured at baseline and 12 months after randomization. The desired TG levels were defined as circulating TG < 150 mg/dL, and LDL levels were targeted as <70 mg/dL according to the recent guidelines of the European Cardiology Society and the European Atherosclerosis Society. A total of 196 patients with available blood samples at baseline and 12-month follow-up were included (94 randomized to CPAP, 102 to no-CPAP). We found no significant between-group differences in circulating levels of TG, TC, HDL and LDL at baseline and after 12 months as well as in the amount of change from baseline. However, there was a significant decline regarding the proportion of patients with the desired TG levels from 87.2% to 77.2% in the CPAP group (p = 0.022), whereas there was an increase from 84.3% to 88.2% in the no-CPAP group (n.s.). The desired LDL levels remained low after 12 months in both groups (15.1% vs. 17.2% in CPAP group, and 20.8% vs. 18.8% in no-CPAP group; n.s.). In a multiple linear regression model, the increase in the TG levels was predicted by the increase in body-mass-index (? = 4.1; 95% confidence interval (1.0–7.1); p = 0.009) adjusted for age, sex and CPAP usage (hours/night). CPAP had no lipid-lowering effect in this revascularized cohort with OSA. An increase in body-mass-index predicted the increase in TG levels after 12 months, suggesting that lifestyle modifications should be given priority in adults with CAD and OSA, regardless of CPAP treatment.