Researcher:
Hafız, Ayşenur Meriç

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Ayşenur Meriç

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Hafız

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Hafız, Ayşenur Meriç

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2020 - 20227

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    Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide
    (Wroclaw Medical Univ, 2020) Dogan, Remzi; Gucin, Zuhal; Ozer, Omer Faruk; Yenigun, Alper; Ozturan, Orhan; N/A; Hafız, Ayşenur Meriç; Faculty Member; School of Medicine; 53676
    Background. Tongue tumors, which are oropharyngeal tumors, are increasing in frequency. Pyrrolidine dithiocarbamate (PDTC) is a powerful antioxidant and antitumoral agent. Objectives. To evaluate the protective and therapeutic effects of PDTC in a tongue cancer model induced with 4-nitroquinoline 1-oxide (4-NQO). Material and methods. We included 40 rats in the trial and assigned them randomly to 5 groups. Group 1 (cancer, n = 7): 4-NQO (0-12 weeks); group 2 (protection, n = 8): 4-NQO (0-12 weeks) + PDTC (300 mg/kg/day, 0-12 weeks); group 3 (therapy-high dose, n = 10): 4-NQO (0-12 weeks) + PDTC (600 mg/kg/day, weeks 12-30); group 4 (therapy-low dose, n = 10): 4-NQO (0-12 weeks) + PDTC (300 mg/kg/day, weeks 12-30); and group 5 (control). Cardiac blood samples were taken to analyze oxidative stress parameters (total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)). Histopathological assessment was performed under a light microscope. Results. The results of the histopathological assessment showed that the model we used in group 1 was successful, which was consistent with the literature. The PDTC dose administered in group 2 could not prevent tumor formation. Group 3 demonstrated that PDTC in high doses is effective as a therapeutic agent. Group 4 indicated that PDTC in low doses has no therapeutic effect. The results of the biochemical assessment showed that in group 3, TOS and OSI values were significantly lower than in groups 1, 2 and 4. No significant difference was found in the TOS and OSI values between groups 5 and 3. Conclusions. Our study demonstrated histopathologically that in an experimentally generated tongue cancer model, application of 600 mg/kg/day of PDTC led to a significant reduction in the size of the tumor. This was supported by the biochemical parameters.
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    PublicationMetadata only
    Subglottic cysts in preterm infants: superficially located cysts versus deeply buried cysts in the mucosa
    (Springer, 2022) Ünsaler, Selin; Gökler, Ozan; Altuntaş, Muzaffer Ozan; Hafız, Ayşenur Meriç; Ünal, Ömer Faruk; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 167909; 311179; 169795; 53676; 199800
    Purpose: To analyze the reason for the diversity of the clinical course of subglottic cysts and discuss their pre- and coexistence with subglottic stenosis. Methods: The medical records of patients who were treated for subglottic cysts between 2003 and 2020 were retrospectively reviewed and direct laryngoscopy videos were analyzed to assess the healing patterns of their disease. Results: Of the 15 patients, 10 had a history of intubation in the neonatal period. In 11 patients, the cysts were transparent and well defined, and no recurrence of subglottic cysts occurred after the initial surgery. In four patients, the cysts were located deep in the mucosa and did not have the typical appearance of a cyst, but rather of a stenotic segment; all of them had a history of intubation and three of them required laryngotracheal reconstruction. Conclusion: Transparent, thin-walled superficial subglottic cysts with healthy surrounding mucosa can easily be treated with endoscopic marsupialization; however, the treatment of deep subglottic cysts can be challenging. The coexistence of subglottic cysts and subglottic stenosis is not rare. We point out the need for considering the possibility of a missed deep submucosal cyst in a seemingly refractory case of pediatric subglottic stenosis with atypical endoscopic findings and with a background history of prior intubation.
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    PublicationOpen Access
    Comparison of nasopharyngeal swab and nasopharyngeal aspiration in adults for SARS-COV-2 identification using reverse transcription-polymerase chain reaction
    (Wiley, 2021) Altuntaş, Muzaffer Ozan; Gökler, Ozan; Hafız, Ayşenur Meriç; Ünsaler, Selin; Okan, Ayşe; Tekin, Süda; Teaching Faculty; Teaching Faculty; Faculty Member; Teaching Faculty; School of Medicine; Koç University Hospital; 169795; 311179; 53676; 167909; N/A; 42146
    We aimed to compare reverse transcription-polymerase chain reaction (RT-PCR) results of nasopharyngeal aspiration (NA) and nasopharyngeal swab (NS) samples in the diagnosis of coronavirus disease 2019. NS was obtained with a dacron swab and NA was performed by aspiration cannula. The sampling was performed by an otolaryngologist to ensure standardized correct sampling from the nasopharynx. RT-PCR was performed for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The level of agreement between the result of NA and NS samples for each patient was analyzed. The Ct values were compared. Thirty-three patients were enrolled in the study with a mean age of 56.3 years. Thirteen subjects resulted negative with both NS and NA; 20 subjects resulted positive with NA and 18 subjects resulted positive with NS. The mean values of Ct for NA samples and NS samples were 24.6 +/- 5.9 and 24 +/- 6.7, respectively. There was no statistical difference between Ct values of NA and NS samples (p = 0.48). RT-PCR for SARS-Cov2 performed with NA sample and NS sample showed a strong correlation regarding the positivity/negativity and the Ct values.
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    PublicationOpen Access
    The effect of COVID-19 pandemic on sudden idiopathic sensorineural hearing loss: a cross-sectional study in a single institution
    (Bayçınar Tıbbi Yayıncılık ve Reklam Hizmetleri, 2022) Ünsaler, Selin; Hafız, Ayşenur Meriç; Şahin, Selin Merve; Aydoğan, Esra; Gökler, Ozan; Altuntaş, Muzaffer Ozan; Faculty Member; Undergraduate Student; Teaching Faculty; Teaching Faculty; School of Medicine; Koç University Hospital; 167909; N/A; N/A; N/A; 311179; 169795
    Objectives: this study aimed to evaluate the effects of the coronavirus disease 2019 (COVID-19) pandemic on the incidence, course, and prognosis of sudden idiopathic sensorineural hearing loss (SISNHL). Patients and methods: this retrospective study was conducted with 55 patients (31 males, 24 females; mean age: 44.4±18.5 years; range, 11 to 83 years) treated for SISNHL. The patients were analyzed in two groups: Group 1, which included 35 patients (24 males, 11 females; mean age: 42.5±18.8 years; range, 11 to 72 years) admitted after the onset of the pandemic between March 2020 and March 2021, and Group 2, which consisted of 20 patients (7 males, 13 females; mean age: 47.5±19.0 years; range, 20 to 83 years) admitted before the pandemic between March 2019 and February 2020. Age, the timing of referral to the otolaryngology clinic after the perception of the first otologic symptom, the severity of the hearing loss, and the status of recovery were investigated. The COVID-19 status of Group 1 was investigated. Results: the incidence of SISNHL among all patients admitted to our clinic in the same time duration was found to have increased after the COVID-19 pandemic, and this increase was statistically significant (p=0.04). One patient had SISNHL during acute COVID-19. Three patients had COVID-19 three weeks before SISNHL, six patients had COVID-19 three months before SISNHL, and one patient was diagnosed with COVID-19 six months before SISNHL. Fourteen patients were tested for severe acute respiratory syndrome coronavirus 2 with real-time polymerase chain reaction at the time of admission, which resulted in negative. Conclusion: as the incidence of SISNHL has increased following the COVID-19 pandemic, a possible relation between hearing loss, presenting as SISNHL, and COVID-19 disease should be investigated. / Amaç: bu çalışmada, koronavirüs hastalığı 2019 (COVID-19) pandemisinin ani idiyopatik sensörinöral işitme kaybının (AİSİK) insidansı, seyri ve prognozu üzerindeki etkileri değerlendirildi. Hastalar ve yöntemler: bu retrospektif çalışma, AİSİK için tedavi edilen 55 hasta (31 erkek, 24 kadın; ort. yaş: 44.4±18.5 yıl; dağılım, 11-83 yıl) ile yürütüldü. Hastalar iki grupta analiz edildi: Mart 2020 ile Mart 2021 arasında pandemi başlangıcından sonra başvuran 35 hastadan (24 erkek, 11 kadın; ort. yaş: 42.5±8.8 yıl; dağılım, 11-72 yıl) oluşan Grup 1 ve Mart 2019 ile Şubat 2020 arasında pandemi öncesi başvuran 20 hastadan (7 erkek, 13 kadın; ort. yaş: 47.5±19.0 yıl; dağılım, 20-83 yıl) oluşan Grup 2. Yaş, ilk otolojik semptomun algılanmasından sonra kulak burun boğaz polikliniğine başvuru zamanlaması, işitme kaybının şiddeti ve iyileşme durumu araştırıldı. Grup 1’in COVID-19 durumu araştırıldı. Bulgular: kliniğimize aynı süre içinde başvuran tüm hastalarda AİSİK insidansının COVID-19 pandemisi sonrası arttığı saptandı ve bu artış istatistiksel olarak anlamlıydı (p=0.04). Bir hastada akut COVID-19 sırasında AİSİK gelişti. Üç hastada AİSİK’den üç hafta önce COVID-19 vardı, altı hastada AİSİK’den üç ay önce COVID-19 vardı ve bir hastada AİSİK’den altı ay önce COVID-19 tanısı konulmuştu. On dört hasta başvuru sırasında şiddetli akut solunum yolu sendromu koronavirüsü 2 için gerçek zamanlı polimeraz zincir reaksiyonu ile test edildi ve sonuç negatif çıktı. Sonuç: COVID-19 pandemisini takiben AİSİK insidansı arttığı için AİSİK olarak ortaya çıkan işitme kaybı ile COVID-19 hastalığı arasındaki olası ilişki araştırılmalıdır.
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    PublicationOpen Access
    Pediatric laryngeal measurements based on computed tomography images
    (Aves, 2022) Ünsaler, Selin; Gökler, Ozan; Aygün, Murat Serhat; Şahin, Selin Merve; Yaycıoğlu, Arda; Altuntaş, Muzaffer Ozan; Ünal, Ömer Faruk; Hafız, Ayşenur Meriç; Teaching Faculty; Teaching Faculty; Undergraduate Student; Other; Faculty Member; School of Medicine; Koç University Hospital; 167909; N/A; N/A; N/A; N/A; N/A; N/A; N/A
    Background: this study aimed to establish average laryngeal measurements in the Turkish pediatric population and measure the narrowest portion of the pediatric airway. Methods: the laryngeal measurements of 88 pediatric patients between the ages 0 and 17 were retrospectively obtained from neck computed tomography scans performed between January 2018 and May 2021. Subjects were divided into 6 age groups. Four following measurements were made: cricoid anteroposterior, cricoid transverse, subglottic anteroposterior, and subglottic transverse. Cross-sectional areas were calculated using these dimensions. Subglottic cross-sectional area/cricoid crosssectional area ratio for each subject was calculated and patients were divided into 2 groups: group 1, subjects with ratio < 1; group 2, subjects with ratio ? 1. Results: mean age was 8.97 ± 5.7. Mean anteroposterior diameters at subglottis and cricoid ring levels were 13.74 ± 4.45 mm and 13.26 ± 4.39 mm; mean transverse diameters were 7.88 ± 2.62 mm and 9.06 ± 3.12 mm, respectively. The subglottic anteroposterior diameter was greater than cricoid (P < .001), but the transverse diameter was smaller than cricoid (P < .001). Subglottic cross-sectional area was 93.24 ± 59.20 mm2 and cricoid cross-sectional area was 103.61 ± 69.15 mm2 . Subglottic cross-sectional area/cricoid cross-sectional area ratio was smaller than 1 in 69 subjects (group 1; mean=0.85) and equal to or greater than 1 in 19 subjects (group 2; mean=1.33). Conclusion: the narrowest portion of the airway was subglottis immediately below the vocal cords, in contrast to the common belief as to the cricoid ring. Subglottic cross-sectional area/cricoid cross-sectional area ratios showed that the pediatric airway was larger at cricoid (69 subjects, 78.4%), and this ratio does not differ based on age.
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    PublicationOpen Access
    Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide
    (Wroclaw University of Medicine, 2020) Doğan, Remzi; Gücin, Zühal; Özer, Ömer Faruk; Yenigün, Alper; Özturan, Orhan; Hafız, Ayşenur Meriç; Faculty Member; School of Medicine
    Background: tongue tumors, which are oropharyngeal tumors, are increasing in frequency. Pyrrolidine dithiocarbamate (PDTC) is a powerful antioxidant and antitumoral agent. Objectives: to evaluate the protective and therapeutic effects of PDTC in a tongue cancer model induced with 4-nitroquinoline 1-oxide (4-NQO). Material and methods: we included 40 rats in the trial and assigned them randomly to 5 groups. Group 1 (cancer, n = 7): 4-NQO (0-12 weeks); group 2 (protection, n = 8): 4-NQO (0-12 weeks) + PDTC (300 mg/kg/day, 0-12 weeks); group 3 (therapy-high dose, n = 10): 4-NQO (0-12 weeks) + PDTC (600 mg/kg/day, weeks 12-30); group 4 (therapy-low dose, n = 10): 4-NQO (0-12 weeks) + PDTC (300 mg/kg/day, weeks 12-30); and group 5 (control). Cardiac blood samples were taken to analyze oxidative stress parameters (total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)). Histopathological assessment was performed under a light microscope. Results: the results of the histopathological assessment showed that the model we used in group 1 was successful, which was consistent with the literature. The PDTC dose administered in group 2 could not prevent tumor formation. Group 3 demonstrated that PDTC in high doses is effective as a therapeutic agent. Group 4 indicated that PDTC in low doses has no therapeutic effect. The results of the biochemical assessment showed that in group 3, TOS and OSI values were significantly lower than in groups 1, 2 and 4. No significant difference was found in the TOS and OSI values between groups 5 and 3. Conclusions: our study demonstrated histopathologically that in an experimentally generated tongue cancer model, application of 600 mg/kg/day of PDTC led to a significant reduction in the size of the tumor. This was supported by the biochemical parameters. © 2020 by Wroclaw Medical University.
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    PublicationOpen Access
    Is elective cancer surgery feasible during the lock-down period of the COVID-19 pandemic? Analysis of a single institutional experience of 404 consecutive patients
    (Wiley, 2021) Cesur, Ezgi; Kırış, Talat; Giray, Burak; Kulle, Cemil Burak; Azamat, İbrahim Fethi; Ağcaoğlu, Orhan; Dilege, Ece; Erkan, Murat Mert; Balık, Emre; Bilge, Orhan; Buğra, Dursun; Vatansever, Doğan; Taşkıran, Çağatay; Erus, Suat; Yavuz, Ömer; Tanju, Serhan; Dilege, Şükrü; Tarım, Kayhan; Kiremit, Murat Can; Kılıç, Mert; Canda, Abdullah Erdem; Kordan, Yakup; Akyoldaş, Göktuğ; Solaroğlu, İhsan; Sasani, Mehdi; Gökler, Ozan; Ünsaler, Selin; Altuntaş, Muzaffer Ozan; Hafız, Ayşenur Meriç; Şimşek, Sezai Aykın; Deveci, Mehmet Ali; Korkmaz, Murat; Çakar, Nahit; Ergönül, Önder; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Faculty Member; Researcher; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 175476; 218050; 214689; 18758; 176833; 1758; 193687; 134190; 175565; N/A; 214690; 122573; 327605; N/A; N/A; 116202; 157552; N/A; 102059; N/A; 311179; 167909; 169795; 53676; N/A; 206311; N/A; 198906; 110398
    Background: we aimed to assess the feasibility and short-term clinical outcomes of surgical procedures for cancer at an institution using a coronavirus disease 2019 (COVID-19)-free surgical pathway during the peak phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Materials and methods: this was a single-center study, including cancer patients from all surgical departments, who underwent elective surgical procedures during the first peak phase between March 10 and June 30, 2020. The primary outcomes were the rate of postoperative SARS-CoV-2 infection and 30-day pulmonary or non-pulmonary related morbidity and mortality associated with SARS-CoV-2 disease. Results: four hundred and four cancer patients fulfilling inclusion criteria were analyzed. The rate of patients who underwent open and minimally invasive procedures was 61.9% and 38.1%, respectively. Only one (0.2%) patient died during the study period due to postoperative SARS-CoV2 infection because of acute respiratory distress syndrome. The overall non-SARS-CoV2 related 30-day morbidity and mortality rates were 19.3% and 1.7%, respectively; whereas the overall SARS-CoV2 related 30-day morbidity and mortality rates were 0.2% and 0.2%, respectively. Conclusions: under strict institutional policies and measures to establish a COVID-19-free surgical pathway, elective and emergency cancer operations can be performed with acceptable perioperative and postoperative morbidity and mortality.