Researcher:
Boral, Jale

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PhD Student

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Jale

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Boral

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Boral, Jale

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20221

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    The association between Acinetobacter baumannii infections and the COVID-19 pandemic in an intensive care unit
    (Nature Publishing Group (NPG), 2022) N/A; Boral, Jale; Pınarlık, Fatihan; Can, Füsun; Ekinci, Güz; Kuşkucu, Mert Ahmet; Ergönül, Önder; Genç, Zeliha; İrkören, Pelin; Kapmaz, Mahir; Çakar, Nahit; Şentürk, Evren; Yurdakul, Fatma; Dikenelli, Bilge; Tekin, Süda; PhD Student; PhD Student; Faculty Member; Master Student; Faculty Member; Faculty Member; Nurse; Doctor; Doctor; Faculty Member; Faculty Member; Doctor; Doctor; Faculty Member; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; N/A; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; Koç University Hospital; N/A; N/A; 103165; N/A; N/A; 110398; N/A; N/A; N/A; 198906; 48359; N/A; N/A; 42146
    We aimed to describe the increased rate of Acinetobacter baumannii infections during the COVID-19 pandemic and define its significance within the last five years. This study was performed in a tertiary hospital with 280 beds and included all patients infected with A. baumannii in the intensive care unit between January 1, 2018, and June 30, 2022. A. baumannii-infected patients in the intensive care unit 27 months before the pandemic and 27 months during the pandemic were included. Pulsed-field gel electrophoresis was performed to assess clonal relatedness. The infection control measures were specified based on the findings and targeted elimination. In total, 5718 patients were admitted to the intensive care unit from January 1st, 2018, to June 30th, 2022. A. baumannii infection was detected in 81 patients. Compared to the pre-pandemic era, the rate of A. baumannii infection during the pandemic was 1.90 times higher (OR: 1.90, 95% CI: [1.197, 3.033]). Clonality assessment of multidrug-resistant A. baumannii samples revealed eight clusters with one main cluster comprising 14/27 isolates between 2021 and 2022. The case fatality rate of the pre-pandemic and pandemic era was not different statistically (83.33% vs. 81.48%, p=0.835). Univariate analysis revealed the association of mechanical ventilation (p=0.002) and bacterial growth in tracheal aspirate (p=0.001) with fatality. During the COVID-19 pandemic, potential deficits in infection control measures may lead to persistent nosocomial outbreaks. In this study, the introduction of enhanced and customized infection control measures has resulted in the containment of an A. baumannii outbreak.