Researcher:
İşleyen, Fatma Sadife

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Master Student

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Fatma Sadife

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İşleyen

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İşleyen, Fatma Sadife

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20171

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    NEUROD2 regulates stim1 expression and store-operated calcium entry in cortical neurons
    (Soc Neuroscience, 2017) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Department of Physics; Department of Molecular Biology and Genetics; Güner, Gökhan; Güzelsoy, Gizem; İşleyen, Fatma Sadife; Şahin, Gülcan Semra; Akkaya, Cansu; Bayam, Efil; Kotan, Ilgın Eser; Kabakçıoğlu, Alkan; Dunn, Gülayşe İnce; Master Student; Master Student; Master Student; Master Student; PhD Student; Researcher; Master Student; Faculty Member; Other; Department of Physics; Department of Molecular Biology and Genetics; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Sciences; College of Sciences; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 49854; N/A
    Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development.