Researcher: Çeliker, Alpay
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Çeliker, Alpay
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Publication Metadata only Left ventricular dysfunction in a child with asymptomatic pre-excitation: cure with catheter ablation(Elsevier, 2023) N/A; Çetiner, Nilüfer; Çeliker, Alpay; Faculty Member; Other; School of Medicine; 181047; N/AWolff-Parkinson-White syndrome, is known to cause left ventricular dysfunction or dilated cardiomyopathy secondary to sustained tachycardia in infants and children. However, left ventricular dysfunction secondary to pre-excitation related abnormal ventricular activation has been reported in a limited number of cases. This condition should be recognized early, as catheter ablation of the accessory pathway can permit rapid ventricular function improvement. In this paper, we present a 2.5-year-old patient diagnosed with tachycardia-free Wolff -Parkinson-White syndrome with a right free wall accessory pathway and depressed cardiac function, whose left ventricular function is completely restored after successful catheter cryoablation.Publication Metadata only Evaluation of the relationship between cardiopulmonary exercise test findings and clinical status in children and adolescents with congenital heart disease(Turkish National Pediatric Society, 2022) Çetiner, Nilüfer; Çeliker, Alpay; Faculty Member; Other; School of Medicine; School of Medicine; 181047; N/ABackground. The cardiopulmonary exercise test is accepted as a helpful diagnostic tool in risk stratification, evaluation of prognosis, and guiding treatment modality in adults with congenital heart disease. In this study, we present our experience with the use of cardiopulmonary exercise test in children with congenital heart disease in different physiological and anatomical classifications. Methods. In this retrospective study, 25 children and adolescents who applied to the pediatric cardiology outpatient clinic between 2017 and 2020 with the diagnosis of different types of congenital heart disease were included. Demographic characteristics, electrocardiogram, echocardiogram, cardiopulmonary exercise test, spirometry, pro-BNP values, and in selected 20 patients; cardiac MRI data were examined. The modified Ross classification was used for heart failure grading. Results. The mean age of the patients was 14.8 ±2.39 years. Fifteen (60%) of the patients were male and 10 (40%) were female. In the modified Ross classification, patients in group I-II had significantly higher maximum exercise time, heart rate reserve %, peak VO2, and VO2/kg values compared to those in group III (p=0.026, p=0.007, p=0.043, p= 0.018, respectively). Cardiopulmonary exercise test and spirometry values obtained from the patients were evaluated in the light of clinical and other laboratory findings, and surgical/interventional treatment was decided for 4 patients with the use of these test results. Conclusions. Cardiopulmonary exercise test is a useful noninvasive diagnostic tool in guiding the treatment decision and predicting the prognosis of pediatric patients with congenital heart disease, who have borderline symptoms. © 2022, Turkish National Pediatric Society. All rights reserved.Publication Metadata only The impact of rapid left ventricular pacing during pediatric aortic valvuloplasty on postprocedural aortic ınsufficiency(Wiley-Blackwell, 2016) Ertugrul, Ilker; Karagoz, Tevfik; Alehan, Dursun; Ozer, Sema; Ozkutlu, Suheyla; N/A; Çeliker, Alpay; Other; School of Medicine; Koç University Hospital; N/AObjective. This study aims to determine efficacy and safety of rapid left ventricular pacing (RLVP) during balloon aortic valvuloplasty and effect on development of postprocedural aortic insufficiency (AI) in children. Design. This is a retrospective comparison of 56 children (mean age 18.3 month; 1 day-15 years of age) who underwent valvuloplasty by using RLVP with standard method (without pacing) during same time period (74 children; mean age 12.6 month; 1 day-18 years of age). Results. The systolic valvular gradient decreased from a mean 67 +/- 20.4 mm Hg (26-120 mm Hg) before the procedure to a mean 27.6 +/- 17.8 mm Hg (0-120 mm Hg) after the procedure. Procedure failed in two of the patients (3.6%) who received the RLVP; only two patients developed severe AI. Among those patients who underwent the standard method procedure failed in 6 patients (8.3%), whereas severe AI was seen in 15 (20.2%). RLVP decreased the incidence of postprocedure severe AI significantly (P < .01) but it had no effect on the gradient reduction of the procedure (P > .05). RLVP did not change the procedure duration, but decreased the duration of fluoroscopy significantly (P < .01). Conclusion. RLVP can be used effectively and safely for pacing during balloon aortic valvuloplasty procedures in all age groups; it decreases procedural failure rate, eases the procedure and prevents the development of AI through the stabilization of the balloon.Publication Metadata only The real world: cost considerations according to geographic location(CRC Press, 2021) Knecht, Maria Miszczak; N/A; Çeliker, Alpay; Other; School of Medicine; N/ACatheter ablation procedures in children and patients with congenital heart disease have always been difficult in many ways, due to abnormal or altered anatomy, variations in the cardiac conduction system, and difficulty in reaching desired positions secondary to venous occlusion. In an ideal world, one would have availability of all modern mapping methods with image embedded systems, new ablation catheters, intracardiac echocardiography, and hybrid intervention capability. These modern technologies have been met with increased success and very low radiation exposure for both patients and physicians. These kinds of equipment may be very costly and are not affordable in some countries with limited resources. The goal of this chapter is to present how clinicians have found ways to provide services for children in need of them.Publication Metadata only Midterm results of implantable cardioverter defibrillators in children and young adults from a single center in Turkey(Wiley, 2016) Aykan, Hayrettin Hakan; Karagöz, Tevfik; Gülgün, Mustafa; Ertuğrul, İlker; Aypar, Ebru; Özer, Sema; Alehan, Dursun; Özkutlu, Süheyla; Çeliker, Alpay; Other; School of Medicine; N/ABackground: Despite concerns about complications with the implantable cardioverter defibrillator (ICD), it is effective for the prevention of sudden cardiac death (SCD). We aimed to analyze our midterm experience with ICD in children and young adults. Methods: This retrospective study included patients who were implanted with an ICD between 2001 and 2014. Demographic characteristics, clinical information, shock features, and complications for all patients with ICD were analyzed. The study population was divided into two groups: early-era patients implanted before 2008, and late-era patients implanted after 2008. Results: Sixty-nine patients (median age: 12 years, median follow-up: 52 months) were implanted with an ICD. Diagnostic categories were channelopathy (56.6%), cardiomyopathy (36.2%), congenital heart disease (5.8%), and other (1.4%). We performed implantation for primary prevention in 66.6% (39.3% in early-era patients and 85.4% in late-era patients). Thirty-one (44.9%) received 139 appropriate shocks (66% of total shocks) while 14 (20.2%) received 71 inappropriate shocks. However, there was no statistically significant difference in the use of appropriate shocks in the primary (66.7%) versus the secondary (72.2%) prevention groups. The incidence of appropriate and inappropriate shock was 66.7% and 33.3% in the primary prevention group, and 72.2% and 27.8% in the secondary prevention group, respectively. Two patients died, although only one death was the result of a lead problem. Conclusions: Although lead integrity problems, inappropriate shocks, and infections are significant issues, ICD therapy appears to be a safe, effective, and necessary option for the prevention of SCD in both children and young adults.Publication Metadata only Pacemaker lead-induced tricuspid stenosis treated with percutaneous valvotomy(Turkish National Pediatric Society, 2020) Özyiğit, Tolga; Çetiner, Nilüfer; Çeliker, Alpay; Baştuhan, Işıl Yıldırım; Mutluer, Ferit Onur; Faculty Member; Other; Doctor; Doctor; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; Koç University Hospital; 181047; N/A; N/A; N/ABackground. Tricuspid stenosis is an uncommon complication of ventricular pacemaker electrode implantation, with few cases reported in the literature. Case. We present an 18-year-old male who developed severe tricuspid stenosis 15 years after endocardial VVI pacemaker implantation for complete AV block following a surgically repaired ventricular septal defect. Conclusion. In this case we have shown that percutaneous balloon valvuloplasty was performed and successful in treating this complication.Publication Metadata only Platypnea-orthodeoxia syndrome in a child: relief of symptoms after transcatheter closure of patent foramen ovale(Cambridge Univ Press, 2021) N/A; N/A; N/A; Çetiner, Nilüfer; Uyan, Zeynep Seda; Çeliker, Alpay; Faculty Member; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; 181047; 153502; N/APlatypnea-orthodeoxia syndrome is a rare clinical entity characterised by positional dyspnoea and arterial desaturation while in the upright position, the symptoms generally occurring in adults. We describe a 12-year-old girl diagnosed with platypnea-orthodeoxia syndrome associated with patent foramen ovale. the symptoms resolved following percutaneous patent foramen ovale closure.Publication Metadata only Transcatheter baffle leak closure via an amplatzer septal occluder in a senning-operated child(Cambridge Univ Press, 2020) Yıldırım Baştuhan, Işıl; N/A; N/A; Çetiner, Nilüfer; Çeliker, Alpay; Faculty Member/Doctor; Other; School of Medicine; School of Medicine; Koç University Hospital; 181047; N/ASenning operation is a surgical treatment for transposition of great arteries that can be complicated by post-procedural atrial or caval baffle leaks. We present a 6-year-old boy with a history of Senning repair for transposition of great arteries, who developed a pulmonary venous baffle leak. Percutaneous baffle leak closure was successfully performed using an Amplatzer septal occluder.Publication Metadata only Next Generation Sequencing (NGS) panel revealed new candidate genes and variants in 25 Hypertrophic Cardiomyopathy patients(NATURE PUBLISHING GROUP, 2019) Turkgenc, B.; Temel, S. G.; Uysal, F.; Atik, S. Ugan; Oztunc, F.; Sulu, A.; Ekici, F.; Ayabakan, C.; Odemis, E.; Saygili, A.; Koka, A.; Akinci, I. Ozkan; Alanay, Y.; Ozer, A.; Yakicier, M. C.; N/A; Çeliker, Alpay; Other; N/A; School of Medicine; N/A; N/AN/APublication Metadata only Kawasaki disease shock syndrome: a rare and severe complication of Kawasaki disease(Turkish J Pediatrics, 2016) Çakan, Mustafa; Gemici, Hakan; Aktay Ayaz, Nuray; Keskindemirci, Gonca; Bornaun, Helen; İkizoğlu, Tarkan; Çeliker, Alpay; Other; School of Medicine; N/AKawasaki disease is an acute systemic vasculitis that occurs most commonly in young children. It affects medium-sized muscular arteries and the coronary arteries are the predominant site of involvement. Morbidity and mortality is generally due to coronary artery aneurysms that develop during the chronic phase. Although it is well known that Kawasaki disease can cause myocarditis, tachycardia and heart failure during acute stage, Kawasaki disease shock syndrome has been recently described. It is characterized by hypotension, signs and symptoms of poor perfusion and a shock-like state. Herein we describe two cases of Kawasaki disease shock syndrome that were treated in the pediatric intensive care unit and followed a course without morbidity or mortality.