Researcher:
Gümüş, Terman

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Doctor

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Terman

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Gümüş

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Gümüş, Terman

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2020 - 20214

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Researcher Of Publications: search.filters.isAuthorOfPublication.809d5efc-a393-49e5-b8b9-4d774e84441e

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    In-bore MRI-guided prostate biopsy in a patient group with PI-RADS 4 and 5 targets: a single center experience
    (Elsevier Ireland Ltd, 2021) Vural, M.; Coskun, B.; Kilic, M.; Durmaz, S.; Onay, A.; Saglican, Y.; Colakoglu, B.; Akpek, S.; Yildirim, H.; Esen, T.; Rozanes, I.; Gümüş, Terman; Cengiz, Duygu; Doctor; Doctor; N/A; N/A; Koç University Hospital; N/A; N/A
    Purpose: To determine the diagnostic yield of magnetic resonance imaging (MRI) guided in-bore biopsy in patients with high likelihood multiparametric MRI (mpMRI) findings, regarding overall and clinically significant prostate cancer (csPCa) detection rates and concordance of biopsy and radical prostatectomy (RP) Gleason scores (GS). Methods: This retrospective study consisted of 277 Prostate Imaging Reporting and Data System (PI-RADS) assessment category 4 and 5 targets in 246 patients (mean age, 65.7 years; median prostate specific antigen value, 7.75 ng/mL) who had undergone in-bore biopsy at our institution between 2012 and 2020. Eighty-one patients who underwent RP were eligible for the concordance analysis of biopsy and RP specimen GS. Results: Overall PCa detection rates were 80.5 % per patient (198/246) and 78 % per target (216/277) and 83.5 % and 67.4 % in primary (biopsy naive) and secondary (at least one negative prior biopsy) settings. csPCa was found in 63 % overall, 66 % of patients (132/200) in the primary, and 50 % of patients (23/46) in the secondary biopsy settings (p < 0.001). The prostate cancer detection rate was 68 % and 92 % in PI-RADS 4 and 5, respectively (p < 0.001). In the radical prostatectomy subcohort, 27.2 % of patients were upgraded, 8.6 % of patients were downgraded from needle biopsy. Significant complications occurred in 1.2 % of patients. Conclusions: MRI-guided in-bore prostate biopsy has a high detection rate of csPCa in primary and secondary biopsy cohorts. Biopsy results were satisfactory in terms of the number of positive cores, cancer percentage in positive cores, and concordance of GS in needle biopsy and RP specimen. © 2021 Elsevier B.V.
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    PublicationOpen Access
    Changes in computed tomography findings of COVID-19 pneumonia: less extensive lung involvement with decreasing disease prevalence
    (Wiley, 2020) Gümüş, Terman; Cengiz, Duygu; Kartal, Furkan; Atçeken, Zeynep; Tekin, Süda; Atasoy, Kayhan Çetin; Doctor; Faculty Member; School of Medicine
    It has been observed that the degree of pulmonary involvement shown in chest computed tomography (CT) scans tended to decrease as the prevalence of coronavirus disease 2019 (COVID-19) infection decreased in the Turkish population. The purpose of this study was to investigate the relationship between the disease severity based on chest CT scans and the temporal evolution of the epidemic. This study recruited 179 patients with confirmed COVID-19 disease who had received a chest CT scan between March 14 and April 28, 2020. The participants were divided into three successive temporal groups based on their date of CT examination. The early (March 14-29), mid (March 30-April 13), and late (April 14-28) groups were compared regarding the presence and extent of pulmonary involvement and CT characteristics of lesions. COVID-19 pneumonia was less extensive in participants under 45 years of age and patients presenting late in the course of epidemic (i.e., the late group) compared those presenting earlier. When each group was subcategorized on the basis of age, older patients in the late group had less extensive lung involvement than older patients in the early group. However, there was no significant difference in the extent of lung involvement in younger patients between the late and early groups. The severity of COVID-19 pneumonia appears to be variable at different temporal windows of the epidemic curve and decreases in patients presenting in the later weeks compared to the earlier weeks, particularly in older patients.
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    PublicationOpen Access
    Preoperative computerized tomography screening for COVID-19 pneumonia in asymptomatic patients: experiences from two centers
    (Springer, 2020) Kabaoğlu, Zeynep Ünal; Coşkun, Bilgen; Artukoğlu, Feyzi; Gümüş, Terman; Kartal, Furkan; Atasoy, Kayhan Çetin; Faculty Member; School of Medicine; Koç University Hospital
    Purpose: the aim of this retrospective study is to evaluate the preoperative screening performance of chest CT (computerized tomography) examination to detect COVID-19 positive individuals. Materials and methods: in this retrospective study 218 adult patients who had preoperative chest CT and RT-PCR were enrolled. CT imaging results, which have been reported according to the Radiological Society of North America expert consensus on COVID-19, were collected from the picture archiving and communicating system. Demographic data, planned surgeries, and postoperative outcomes were collected from the electronic patient records. Results: one patient (0.5%) showed typical CT features for COVID-19 pneumonia; 12 patients (5.5%) were reported as indeterminate, and eight (3.7%) were reported as atypical for COVID-19 pneumonia. Only one of the three patients with positive RT-PCR had abnormalities on CT. When RT-PCR tests were taken as reference, the sensitivity, specificity, and accuracy of chest CT in showing COVID-19 infection in asymptomatic patients were 33.3%, 90.7%, and 90.0%, respectively. Conclusion: chest CT screening for COVID-19 has a very low yield in asymptomatic preoperative patients and shows false-positive findings in 9.2% of cases, potentially leading to unnecessary postponing of the surgery.
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    PublicationOpen Access
    Targeted follow-up of incidental lung nodules: will the new nodules in unscanned regions be missed?
    (Galenos Yayınevi, 2021) Uçar, Gökhan; Gümüş, Terman; Koç University Hospital
    Objective: targeted computed tomography (TCT) scans a limited part or those parts of the lung with nodules that require follow-up. In order to apply targeted tomography safely, it is important to know the frequency of newly appearing nodules in unscanned regions of lung. We aimed to evaluate the frequency and importance of new pulmonary nodules that appear in patients followed-up for nodules according to Fleischner society guidelines. Methods: A total of 117 patients (women: 54; men: 63; mean age: 55 +/- 14 years; range: 30-88 years) who were followed-up for 265 lung nodules were included in this study. The inclusion criteria was presence of at least 1 nodule that was followed-up for at least 6 months with CT. Patients with calcified nodules or known malignancy during initial CT were excluded. Results: the median follow-up time was 22 months (range: 6-80 months) and the median number of follow-up CT scans was 2 (range: 1-5). New nodules appeared only in 6% (7/117) of the patients, of which 5 had nodules that disappeared or decreased in size during follow-up. Conclusion: for patients who were followed-up for pulmonary nodules, the frequency of new nodule formation was low. This should encourage the use of TCT for nodule follow-up. With an appropriate TCT follow-up schedule, patients will receive reasonably low radiation levels without affecting their management.