Researcher:
Altunsu, Deniz

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PhD Student

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Deniz

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Altunsu

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Altunsu, Deniz

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20222

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Researcher Of Publications: search.filters.isAuthorOfPublication.899f5ba6-37e7-4556-96af-2ac42d4c0fe1

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    Targeting the blood–brain barrier disruption in hypertension by ALK5/TGF-В type I receptor inhibitor SB-431542 and dynamin inhibitor dynasore
    (Elsevier, 2022) Ayvaz, Ecem; Yılmaz, Canan Uğur; Girouard, Helene; Atış, Müge; Akcan, Uğur; Altunsu, Deniz; Sarıkaya, Deniz; Temizyürek, Arzu; Ahıshalı, Bülent; Kaya, Mehmet; PHD Student; PHD Student; PHD Student; Undergraduate Student; Other; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; 9509; 10486
    Introduction: In this study, we aimed to target two molecules, transforming growth factor-beta (TGF-beta) and dynamin to explore their roles in blood-brain barrier (BBB) disruption in hypertension. Methods: For this purpose, angiotensin (ANG) II-induced hypertensive mice were treated with SB-431542, an inhibitor of the ALK5/TGF-beta type I receptor, and dynasore, an inhibitor of dynamin. Albumin-Alexa fluor 594 was used to assess BBB permeability. The alterations in the expression of claudin-5, caveolin (Cav)-1, glucose transporter (Glut)-1, and SMAD4 in the cerebral cortex and the hippocampus were evaluated by quantification of immunofluorescence staining intensity.Results: ANG II infusion increased BBB permeability to albumin-Alexa fluor 594 which was reduced by SB431542 (P < 0.01), but not by dynasore. In hypertensive animals treated with dynasore, claudin-5 immunofluorescence intensity increased in the cerebral cortex and hippocampus while it decreased in the cerebral cortex of SB-431542 treated hypertensive mice (P < 0.01). Both dynasore and SB-431542 prevented the increased Cav-1 immunofluorescence intensity in the cerebral cortex and hippocampus of hypertensive animals (P < 0.01). SB431542 and dynasore decreased Glut-1 immunofluorescence intensity in the cerebral cortex and hippocampus of mice receiving ANG II (P < 0.01). SB-431542 increased SMAD4 immunofluorescence intensity in the cerebral cortex of hypertensive animals, while in the hippocampus a significant decrease was noted by both SB-431542 and dynasore (P < 0.01).Conclusion: Our data suggest that inhibition of the TGF beta type I receptor prevents BBB disruption under hypertensive conditions. These results emphasize the therapeutic potential of targeting TGF beta signaling as a novel treatment modality to protect the brain of hypertensive patients.
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    IgG-Conjugated gold nanoparticles restore blood-brain barrier damage in both in vitro and in vivo models of sepsis
    (Wiley, 2022) Esen, Figen; Orhun, Gunseli; Ozcan, Perihan Ergin; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; N/A; N/A; N/A; Akcan, Uğur; Çavuşlar, Özge; Acar, Havva Funda Yağcı; Temizyürek, Arzu; Bakbak, Haşim; Altunsu, Deniz; Ayvaz, Ecem; Ahıshalı, Bülent; Kaya, Mehmet; PhD Student; PhD Student; Faculty Member; Other; Doctor; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Chemistry; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; College of Sciences; N/A; School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; N/A; N/A; N/A; N/A; 178902; 357912; N/A; N/A; N/A; 9509; 10486
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