Researcher:
Taşoğlu, Savaş

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Savaş

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Taşoğlu

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Now showing 1 - 10 of 48
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    Biomedical optical fibers
    (Royal Soc Chemistry, 2021) Jiang, Nan; Yetişen, Ali K.; N/A; N/A; Department of Mechanical Engineering; Sarabi, Misagh Rezapour; Öztürk, Ece; Taşoğlu, Savaş; PhD Student; Faculty Member; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Graduate School of Sciences and Engineering; School of Medicine; College of Engineering; N/A; 326940; 291971
    Optical fibers with the ability to propagate and transfer data via optical signals have been used for decades in medicine. Biomaterials featuring the properties of softness, biocompatibility, and biodegradability enable the introduction of optical fibers' uses in biomedical engineering applications such as medical implants and health monitoring systems. Here, we review the emerging medical and health-field applications of optical fibers, illustrating the new wave for the fabrication of implantable devices, wearable sensors, and photodetection and therapy setups. A glimpse of fabrication methods is also provided, with the introduction of 3D printing as an emerging fabrication technology. The use of artificial intelligence for solving issues such as data analysis and outcome prediction is also discussed, paving the way for the new optical treatments for human health.
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    Additive manufacturing and three-dimensional printing in obstetrics and gynecology: a comprehensive review
    (Springer, 2023) Yaşlı, Mert; Dabbagh, Sajjad Rahmani; Taşoğlu, Savaş; Aydın, Serdar; Undergraduate Student; PhD Student; Faculty Member; Faculty Member; School of Medicine; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; 291971; 132535
    Three-dimensional (3D) printing, also known as additive manufacturing, is a technology used to create complex 3D structures out of a digital model that can be almost any shape. Additive manufacturing allows the creation of customized, finely detailed constructs. Improvements in 3D printing, increased 3D printer availability, decreasing costs, development of biomaterials, and improved cell culture techniques have enabled complex, novel, and customized medical applications to develop. There have been rapid development and utilization of 3D printing technologies in orthopedics, dentistry, urology, reconstructive surgery, and other health care areas. Obstetrics and Gynecology (OBGYN) is an emerging application field for 3D printing. This technology can be utilized in OBGYN for preventive medicine, early diagnosis, and timely treatment of women-and-fetus-specific health issues. Moreover, 3D printed simulations of surgical procedures enable the training of physicians according to the needs of any given procedure. Herein, we summarize the technology and materials behind additive manufacturing and review the most recent advancements in the application of 3D printing in OBGYN studies, such as diagnosis, surgical planning, training, simulation, and customized prosthesis. Furthermore, we aim to give a future perspective on the integration of 3D printing and OBGYN applications and to provide insight into the potential applications.
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    Magnetic levitation for space exploration
    (Elsevier Science London, 2022) Yetişen, Ali K.; N/A; Department of Mechanical Engineering; Sarabi, Misagh Rezapour; Taşoğlu, Savaş; PhD Student; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Graduate School of Sciences and Engineering; College of Engineering; N/A; 291971
    Magnetic levitation allows for simulating the microgravity conditions to advance bottom-up tissue engineering, forging regenerative medicine ahead to enable space exploration. Here, magnetic levitation methods for microgravity studies and the biofabrication of 3D cellular structures are discussed.
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    Nanotechnology-based electrochemical biosensors for monitoring breast cancer biomarkers
    (John Wiley and Sons Inc, 2022) Nasrollahpour, Hassan; Khalilzadeh, Balal; Hasanzadeh, Mohammad; Rahbarghazi, Reza; Estrela, Pedro; Naseri, Abdolhossein; Sillanpää, Mika; Department of Mechanical Engineering; Taşoğlu, Savaş; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; 291971
    Breast cancer is categorized as the most widespread cancer type among women globally. On-time diagnosis can decrease the mortality rate by making the right decision in the therapy procedure. These features lead to a reduction in medication time and socioeconomic burden. The current review article provides a comprehensive assessment for breast cancer diagnosis using nanomaterials and related technologies. Growing use of the nano/biotechnology domain in terms of electrochemical nanobiosensor designing was discussed in detail. In this regard, recent advances in nanomaterial applied for amplified biosensing methodologies were assessed for breast cancer diagnosis by focusing on the advantages and disadvantages of these approaches. We also monitored designing methods, advantages, and the necessity of suitable (nano) materials from a statistical standpoint. The main objective of this review is to classify the applicable biosensors based on breast cancer biomarkers. With numerous nano-sized platforms published for breast cancer diagnosis, this review tried to collect the most suitable methodologies for detecting biomarkers and certain breast cancer cell types.
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    Biomedical applications of magnetic levitation
    (Wiley-V C H Verlag Gmbh, 2022) Alseed, M. Munzer; N/A; N/A; Department of Mechanical Engineering; Department of Mechanical Engineering; Dabbagh, Sajjad Rahmani; Saadat, Milad; Sitti, Metin; Taşoğlu, Savaş; PhD Student; PhD Student; Faculty Member; Faculty Member; Department of Mechanical Engineering; KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; N/A; N/A; 297104; 291971
    Magnetic levitation (MagLev) is a user-friendly, electricity-free, accurate, affordable, and label-free platform for chemical and biological applications owing to its ability to suspend and separate a wide range of diamagnetic materials (e.g., plastics, polymers, cells, and proteins) based on their density. Various MagLev designs (e.g., standard, single and double ring, titled, and rotational MagLev setups) are presented in the literature with a trade-off between sensitivity and detection range. Herein, various MagLev designs, the advantages and pitfalls of each method, and current challenges encountered by MagLev platforms are reviewed. Moreover, end applications of MagLev are presented in single-cell and protein analysis, diseases diagnosis (e.g., cancer and hepatitis C), tissue engineering, 3D self-assembly, and forensic case studies to provide an insight regarding the potentials of MagLev.
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    Recent technological developments in the diagnosis and treatment of cerebral edema
    (Wiley-V C H Verlag Gmbh, 2021) Deshmukh, Karthikeya P.; Jiang, Nan; Yetişen, Ali K.; N/A; Department of Mechanical Engineering; Dabbagh, Sajjad Rahmani; Taşoğlu, Savaş; N/A; Faculty Member; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; 291971
    Latest technological advancements in neurocritical care have translated to improved clinical outcomes and have paved the way for the effective diagnosis and treatment of cerebral edema. Effective management of cerebral edema has the potential to provide a personalized treatment by obtaining the complete pathophysiological information of the patient. The aims of this review are to inform the reader about the research and development in this field in the past decade as well as the materialization of scientific literature through patents. There is a growing interest in multimodal monitoring of the diseased brain as it provides a necessary means to implement effective intervention strategies. Although there is a gradual shift toward the adoption of noninvasive devices for research purposes, their clinical applications are hindered by their inaccuracies. However, the inherent risk of complication and high costs of implementation challenge the status quo. The role of neuroprotectants is explored and the combination of neurodiagnostic and neuroprotective approaches is proposed. Finally, the impacts of the current state of global affairs are discussed and it is predicted that the rising number of traumatic brain injury patents will inevitably translate to improvements in technologies to effectively address cerebral edema.
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    Three-dimensional neurovascular co-culture inside a microfluidic invasion chemotaxis chip
    (Mary Ann Liebert, Inc, 2022) Cücük, Levent; Polat, İrem; N/A; Department of Mechanical Engineering; Sokullu, Emel; Taşoğlu, Savaş; Faculty Member; Faculty Member; Department of Mechanical Engineering; School of Medicine; College of Engineering; 163024; 291971
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    Low-cost optical assays for point-of-care diagnosis in resource-limited settings
    (Amer Chemical Soc, 2021) Jiang, Nan; Tansukawat, Natha Dean; Gonzalez-Macia, Laura; Ateş, H. Ceren; Dinçer, Can; Güder, Fırat; Yetişen, Ali K.; Department of Mechanical Engineering; Taşoğlu, Savaş; Faculty Member; Department of Mechanical Engineering; College of Engineering; 291971
    Readily deployable, low-cost point-of-care medical devices such as lateral flow assays (LFAs), microfluidic paper-based analytical devices (mu PADs), and microfluidic thread-based analytical devices (mu TADs) are urgently needed in resource-poor settings. Governed by the ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverability) set by the World Health Organization, these reliable platforms can screen a myriad of chemical and biological analytes including viruses, bacteria, proteins, electrolytes, and narcotics. The Ebola epidemic in 2014 and the ongoing pandemic of SARS-CoV-2 have exemplified the ever-increasing importance of timely diagnostics to limit the spread of diseases. This review provides a comprehensive survey of LFAs, mu PADs, and mu TADs that can be deployed in resource-limited settings. The subsequent commercialization of these technologies will benefit the public health, especially in areas where access to healthcare is limited.
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    Portable magnetic levitation technologies
    (Walter De Gruyter Gmbh, 2021) Alseed, M. Munzer; Zhao, Peng; N/A; Department of Media and Visual Arts; Department of Mechanical Engineering; Dabbagh, Sajjad Rahmani; Özcan, Oğuzhan; Taşoğlu, Savaş; PhD Student; Faculty Member; Faculty Member; Department of Media and Visual Arts; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; College of Social Sciences and Humanities; College of Engineering; N/A; 12532; 291971
    Magnetic levitation (MagLev) is a density-based method which uses magnets and a paramagnetic medium to suspend multiple objects simultaneously as a result of an equilibrium between gravitational, buoyancy, and magnetic forces acting on the particle. Early MagLev setups were bulky with a need for optical or fluorescence microscopes for imaging, confining portability, and accessibility. Here, we review design criteria and the most recent end-applications of portable smartphone-based and self-contained MagLev setups for density-based sorting and analysis of microparticles. Additionally, we review the most recent end applications of those setups, including disease diagnosis, cell sorting and characterization, protein detection, and point-of-care testing.
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    Electro-conductive silica nanoparticles-incorporated hydrogel based on alginate as a biomimetic scaffold for bone tissue engineering application
    (Taylor and Francis Ltd., 2023) Derakhshankhah, Hossein; Eskandani, Morteza; Vandghanooni, Somayeh; Jaymand, Mehdi; Department of Mechanical Engineering; N/A; Taşoğlu, Savaş; Nakhjavani, Sattar Akbar; Faculty Member; Researcher; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; N/A; 291971; N/A
    An innovative electrically conductive hydrogel was fabricated through the incorporation of silica nanoparticles (SiO2 NPs) and poly(aniline-co-dopamine) (PANI-co-PDA) into oxidized alginate (OAlg) as a biomimetic scaffold for bone tissue engineering application. The developed self-healing chemical hydrogel was characterized by FTIR, SEM, TEM, XRD, and TGA. The electrical conductivity and swelling ratio of the hydrogel were obtained as 1.7 × 10−3 S cm−1 and 130%, respectively. Cytocompatibility and cell proliferation potential of the developed scaffold were approved by MTT assay using MG-63 cells. FE-SEM imaging approved the potential of the fabricated scaffold for hydroxyapatite (HA) formation and bioactivity induction through immersing in SBF solution.