Researcher:
Bayram, Hasan

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Faculty Member

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Hasan

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Bayram

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Bayram, Hasan

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2017 - 2019162020 - 202217

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Researcher Of Publications: search.filters.isAuthorOfPublication.b10f8967-86be-4ea9-8b3e-c698d7fe1c26

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Now showing 1 - 10 of 34
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    The role of reactive nitrogen species as biomarkers of disease severity in COVID-19
    (European Respiratory Society (ERS), 2022) Akyil, F. Tokgoz; Altin, S.; N/A; N/A; N/A; N/A; Department of Molecular Biology and Genetics; N/A; N/A; Konyalılar, Nur; Kayalar, Özgecan; Mortazavi, Deniz; Rajabi, Hadi; Korkunç, Seval Kübra; Erkan, Selim; Gönenli, Mehmet Gökhan; Bayram, Hasan; PhD Student; Researcher; PhD Student; PhD Student; Master Student; Other; Other; Teaching Faculty; Faculty Member; Department of Molecular Biology and Genetics; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; Graduate School of Sciences and Engineering; N/A; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 350445; 4890
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    Loss of the cholesterol metabolizing enzyme CH25H protects against cigarette smoke-induced COPD
    (Amer Thoracic Soc, 2017) Conlon, T. M.; Jia, J.; Gao, J.; Heinzelmann, K.; Tasdemir, D.; Eickelberg, O.; Yildirim, A. O.; Bayram, Hasan; Faculty Member; School of Medicine; 4890
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    Generation of small molecules targeting hypoxia inducible factors
    (European Respiratory Soc Journals Ltd, 2018) Saygideger, Yasemin; Kahraman, Demet; Ilhan, Sedat; Tok, Tugba Taskin; Basaran, Eyup; Iyidogan, Aysegul; Uren, Aykut; Emre, Elcin; Bayram, Hasan; Faculty Member; School of Medicine; 4890
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    Metabolomic regulation of B cells drives the pathogenesis of COPD
    (Amer Thoracic Soc, 2019) Gunsel, G. Gunes; Conlon, T. M.; Sarker, R.; Jia, J.; Heinzelmann, K.; Tasdemir, D.; Bayram, H.; Eickelberg, O.; Yildirim, A. O.; Bayram, Hasan; Faculty Member; School of Medicine; 4890
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    CARM1 regulates senescence during airway epithelial cell injury in COPD pathogenesis
    (American Physiological Society (APS), 2019) Sarker, Rim S. J.; Conlon, Thomas M.; Morrone, Carmela; Srivastava, Barkha; Verleden, Stijn E.; Fehrenbach, Heinz; Yildirim, Ali Onder; N/A; Konyalılar, Nur; Bayram, Hasan; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; N/A; 4890
    Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disease. Although cigarette smoke was considered the main cause of development, the heterogeneous nature of the disease leaves it unclear whether other factors contribute to the predisposition or impaired regeneration response observed. Recently, epigenetic modification has emerged to be a key player in the pathogenesis of COPD. The addition of methyl groups to arginine residues in both histone and nonhistone proteins by protein arginine methyltransferases (PRMTs) is an important posttranslational epigenetic modification event regulating cellular proliferation, differentiation, apoptosis, and senescence. Here, we hypothesize that coactivator-associated arginine methyltransferase-1 (CARM1) regulates airway epithelial cell injury in COPD pathogenesis by controlling cellular senescence. Using the naphthalene (NA)-induced mouse model of airway epithelial damage, we demonstrate that loss of CC10-positive club cells is accompanied by a reduction in CARM1-expressing cells of the airway epithelium. Furthermore, Carm1 haploinsuffficent mice showed perturbed club cell regeneration following NA treatment. In addition, CARM1 reduction led to decreased numbers of antisenescent sirtuin 1-expressing cells accompanied by higher p21, p16, and beta-galactosidase-positive senescent cells in the mouse airway following NA treatment. Importantly, CARM1-silenced human bronchial epithelial cells showed impaired wound healing and higher beta-galactosidase activity. These results demonstrate that CARM1 contributes to airway repair and regeneration by regulating airway epithelial cell senescence.
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    Effects of diesel exhaust particleson ciliary beat frequency of bronchial cells of COPD patients
    (Amer Thoracic Soc, 2018) Tasdemir, D.; Ilhan, S.; Bayram, Hasan; Faculty Member; School of Medicine; Koç University Hospital; 4890
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    Effect of global climate change-related factors on COPD morbidity
    (Shaheed Beheshti University of Medical Sciences and Health Services, 2017) Bayram, Hasan; Faculty Member; School of Medicine; 4890
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    Asthma in the context of global alliance against respiratory diseases (GARD) in turkey
    (AME Publishing Company, 2018) Yorgancioglu, Arzu; Gemicioglu, Bilun; Ekinci, Banu; Ozkan, Zubeyde; Ergan, Begum; Ersu, Refika; Kocabas, Ali; Kokturk, Nurdan; Bayram, Hasan; Faculty Member; School of Medicine; 4890
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    Effect of desert dust storms and meteorological factors on respiratory diseases
    (Wiley, 2022) Bogan, Mustafa; Kul, Seval; Al, Behcet; Oktay, Mehmet Murat; Akpinar Elci, Muge; Pinkerton, Kent E.; N/A; Bayram, Hasan; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 4890
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    Asthma control and adherence in newly diagnosed young and elderly adult patients with asthma in Turkey
    (TAYLOR & FRANCIS LTD, 2019) Gemicioglu, Bilun; Cimrin, Arif; Abadoglu, Oznur; Cilli, Aykut; Uzaslan, Esra; Gunen, Hakan; Akyildiz, Levent; Suerdem, Mecit; Ozlu, Tevfik; Misirligil, Zeynep; Bayram, Hasan; Faculty Member; N/A; School of Medicine; N/A; 4890
    Objective: This study aimed to evaluate the factors that affect asthma control and adherence to treatment in newly diagnosed elderly asthmatics in Turkey compared with younger patients. Methods: This real-life prospective observational cohort study was conducted at 136 centers. A web-based questionnaire was administered to the patients who were followed up for 12 months. Results: Analysis included 1037 young adult asthma patients (age <65 years) and 79 elderly asthma patients (age >= 65 years). The percentage of patients with total control in the elderly and young groups were 33.9% and 37.1% at visit 1, 20.0% and 42.1% (p = 0.012) at visit 2, and 50.0% and 49.8% at visit 3, respectively. Adherence to treatment was similar for both groups. Visit compliance was better in the elderly group than in the young group at visit 1 (72.2% vs. 60.8%, p = 0.045), visit 2 (51.9% vs. 34.9%, p = 0.002), and visit 3 (32.9% vs. 19.4%, p = 0.004). Adherence to treatment increased with asthma control in both groups (both p < 0.001) but decreased with the presence of gastritis/ulcer, gastroesophageal reflux, and coronary artery disease in the elderly. Conclusions: Asthma control and adherence to treatment were similar for the elderly and young asthma patients, though the follow-up rate was lower in young patients. The presence of gastritis/ulcer, gastroesophageal reflux and coronary artery disease had negative impacts on the adherence to treatment in elderly adult patients.