Researcher:
Karabörk, Merve

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Undergraduate Student

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Merve

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Karabörk

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Karabörk, Merve

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2012 - 20196

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Researcher Of Publications: search.filters.isAuthorOfPublication.bc86e565-684a-4a87-b7b0-1a293be45931

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Now showing 1 - 6 of 6
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    Mito tracker labeling in HepG2 cell cultures: influence of different staining techniques on the morphology of mitochondria.
    (Amer Soc Cell Biology, 2012) Karahuseyinoglu, S.; Tok, O. E.; Yucel, D.; Aktaş, Ranan Gülhan; Karabörk, Merve; Faculty Member; Undergraduate Student; School of Medicine; School of Medicine; 137519; 358512
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    Actin distribution in HepG2 cell-spheroids: a fluorescence microscopic study
    (Amer Soc Cell Biology, 2012) Karahuseyinoglu, S.; Tok, O. E.; Yucel, D.; Aktaş, Ranan Gülhan; Karabörk, Merve; Faculty Member; Undergraduate Student; School of Medicine; School of Medicine; 137519; 358512
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    The da Vinci Xi system for robotic total/subtotal colectomy vs. conventional laparoscopy: short‑term outcomes
    (Springer-Verlag Italia Srl, 2019) Ozben, V.; de Muijnck, C.; Bilgin, I. A.; Aytac, E.; Baca, B.; Hamzaoglu, I.; Karahasanoglu, T.; Zenger, S.; N/A; Karabörk, Merve; Özoran, Emre; Balık, Emre; Buğra, Dursun; Undergraduate Student; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 358512; 307296; 18758; 1758
    Background The aim of this study was to evaluate the feasibility of robotic total/subtotal colectomy procedures with the Xi robot and to compare its short-term outcomes with those of conventional laparoscopy. Methods Between October 2010 and September 2018, consecutive patients with colonic neoplasia, inflammatory bowel disease, familial adenomatous polyposis or colonic inertia who underwent elective robotic or laparoscopic total/subtotal abdominal colectomy at two specialized centers in Turkey were included. Data on perioperative characteristics and 30-day outcomes were compared between the two approaches. Results There were a total of 82 patients: 26 and 56 patients in the robotic and laparoscopic group, respectively (54 men and 28 women, mean age 54.7 +/- 17.4 years). The groups were comparable regarding preoperative characteristics. All the robotic procedures were completed with a single positioning of the robot. Estimated blood loss (median, 150 vs 200 ml), conversions (0% vs 14.3%), and complications (0% vs 7.1%) were similar but operative time was significantly longer in the robotic group (median, 350 vs 230 min, p < 0.001). No difference was detected in the length of hospital stay (7.9 +/- 5.7 vs 9.5 +/- 6.0 days, p = 0.08), anastomotic leak (3.8% vs 8.3%), ileus (15.4% vs 19.6%), septic complications, reoperations (7.7% vs 12.5%), and readmissions (19.2% vs 12.5%). The number of harvested lymph nodes in the subgroup of cancer patients was significantly higher in the robotic group (median, 66 vs 50, p = 0.01). Conclusions In total/subtotal colectomy procedures, the robotic approach with the da Vinci Xi platform is feasible, safe, and associated with short-term outcomes similar to laparoscopy but longer operative times and a higher number of retrieved lymph nodes.
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    Effects of volume overload and current techniques for the assessment of fluid status in patients with renal disease
    (Karger Publishers, 2018) Siriopol, Dimitrie; Covic, Adrian; Ekinci, Can; Karabörk, Merve; Dinçer, Neris; Kanbay, Mehmet; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 323478; 358512; 349025; 110580
    Volume overload is an important, may be the foremost, independent prognostic factor determining the outcome of hemodialysis patients. Therefore, it is crucial to measure fluid status of these patients and avoid volume overload. This review aims to evaluate volume overload, its effects on patients with renal diseases and current methodologies measuring volume status in the body. These techniques will be first classified as clinical evaluation and non-clinical and/or instrumental techniques, which includes biomarkers, ultrasonography, relative blood volume monitoring, bioimpedance, echocardiography, pulmonary artery catheterization, esophageal and/or suprasternal Doppler, and blood viscosity. Advantages and limitations of these different techniques will be reviewed extensively by comparing each other. At last, insights gained from this review can highlight the future prospects in this active area of research. (C) 2018 S. Karger AG, Basel.
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    Sox2: regulation of expression and contribution to brain tumors
    (Future Medicine, 2016) Mansouri, Sheila; Nejad, Romina; Aldape, Kenneth D.; Zadeh, Gelareh; N/A; Karabörk, Merve; Ekinci, Can; Solaroğlu, İhsan; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; 323478; 102059
    Tumors of the CNS are composed of a complex mixture of neoplastic cells, in addition to vascular, inflammatory and stromal components. Similar to most other tumors, brain tumors contain a heterogeneous population of cells that are found at different stages of differentiation. The cancer stem cell hypothesis suggests that all tumors are composed of subpopulation of cells with stem-like properties, which are capable of self-renewal, display resistance to therapy and lead to tumor recurrence. One of the most important transcription factors that regulate cancer stem cell properties is SOX2. In this review, we focus on SOX2 and the complex network of signaling molecules and transcription factors that regulate its expression and function in brain tumor initiating cells. We also highlight important findings in the literature about the role of SOX2 in glioblastoma and medulloblastoma, where it has been more extensively studied.
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    DICER governs characteristics of glioma stem cells and the resulting tumors in xenograft mouse models of glioblastoma
    (Impact Journals, 2016) Mansouri, Sheila; Singh, Sanjay; Alamsahebpour, Amir; Burrell, Kelly; Li, Mira; Ekinci, Can; Koch, Elizabeth; Chang, Jeffery T.; Wouters, Bradly; Aldape, Kenneth; Zadeh, Gelareh; N/A; Karabörk, Merve; Solaroğlu, İhsan; Undergraduate Student; Faculty Member; School of Medicine; N/A; 102059
    The RNAse III endonuclease DICER is a key regulator of microRNA (miRNA) biogenesis and is frequently decreased in a variety of malignancies. We characterized the role of DICER in glioblastoma (GB), specifically demonstrating its effects on the ability of glioma stem-like cells (GSCs) to form tumors in a mouse model of GB. DICER silencing in GSCs reduced their stem cell characteristics, while tumors arising from these cells were more aggressive, larger in volume, and displayed a higher proliferation index and lineage differentiation. The resulting tumors, however, were more sensitive to radiation treatment. Our results demonstrate that DICER silencing enhances the tumorigenic potential of GSCs, providing a platform for analysis of specific relevant miRNAs and development of potentially novel therapies against GB.