Researcher:
Özkan, Alev

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Faculty Member

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Alev

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Özkan

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Özkan, Alev

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20213

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Researcher Of Publications: search.filters.isAuthorOfPublication.c157d033-12cd-47cf-93f8-a80363cf9ce4

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    Preoperative prediction of lymph node invasion in prostate cancer: Ga-68 PSMA PET or nomograms?
    (Elsevier, 2021) Kılıç, M.; Musaoğlu, A.; N/A; Kordan, Yakup; Köseoğlu, Ersin; Sarıkaya, Ahmet Furkan; Tarım, Kayhan; Özkan, Alev; Kiremit, Murat Can; Acar, Ömer; Canda, Abdullah Erdem; Balbay, Mevlana Derya; Esen, Tarık; Faculty Member; Faculty Member; Researcher; Researcher; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 157552; 350876; 327615; 327605; 12695; 222920; 237530; 116202; 153320; 50536
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    PublicationOpen Access
    Comparison of anxiety and depression scores between patients with and without ST-segment elevation acute coronary syndrome
    (Bayçınar Tıbbi Yayıncılık ve Reklam Hizmetleri, 2021) Palabıyık, Mert; Sinan, Ümit Yaşar; Çetinarslan, Özge; Oktay, Veysel; Özkan, Alev; Faculty Member; School of Medicine; Koç University Hospital; 12695
    Objectives: we aimed to investigate the difference between anxiety and depression status among ST-segment elevation acute coronary syndrome (STE-ACS) and non-ST-segment elevation ACS (NSTE-ACS) patients. Patients and methods: this study is a cross-sectional study that included 165 patients (132 males, 33 females; mean age: 59.3±10.5 years; range, 48 to 71 years) who were hospitalized with a final diagnosis of ACS (both NSTE-ACS and STE-ACS) between January 2019 and April 2019. The Hospital Anxiety and Depression Scale (HADS) was used to measure the patients’ anxiety and depression status. Results: according to current European Society of Cardiology (ESC) guidelines, 91 (55.2%) patients were classified as NSTE-ACS and 74 (44.8%) patients as STE-ACS. According to the HADS scores, 33 (20%) of the total study population had anxiety diagnoses, and 28 (17%) of them had depression . While the mean depression score was 4.8±4.9 for NSTE-ACS patients, it was 4.6±4.3 for STE-ACS patients (p=0.723). The mean anxiety score was 6.1±5.1 for NSTE-ACS patients and 5.6±4.5 for STE-ACS patients (p=0.546), which was similar between the two groups. Conclusion: although NSTE-ACS and STE-ACS are two different entities of ACS spectrum, patients hospitalized with these diagnoses have similar anxiety and depression scores.
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    PublicationOpen Access
    The frequency of aspirin and clopidogrel resistance and related factors in patients undergoing elective percutaneous coronary intervention
    (Galenos Yayınevi, 2021) Karabulut, Dilay; Kaya, Ayşem; Abacı, Özkan; Karabulut, Umut; Turhan Çağlar, Fatma Nihan; Özkan, Alev; Faculty Member; School of Medicine; 12695
    Objectives: dual antiplatelet therapy with aspirin and a P2Y12 inhibitor is the mainstay of antithrombotic therapy after myocardial infarction and percutaneous coronary interventions (PCI). Despite chronic oral antiplatelet therapy, many atherothrombotic events continue to occur. Several reports in the literature have shown possible relationships between residual platelet activity and clinical outcomes, raising the possibility that “resistance” to oral antiplatelet therapy may underlie such adverse events. In this study, we aimed to determine the prevalence of aspirin and clopidogrel resistance, and related factors. We also aimed to identify the predictors of reduced antiplatelet response among patients undergoing elective PCI for stable coronary artery disease (CAD). Materials and methods: we retrospectively included patients who underwent an elective PCI with available aggregation inhibition test results. According to aggregation inhibition test results, patients were divided into two subgroups: 1-aspirin resistant/low responders and responders 2-clopidogrel resistant/low responders and responders. Results: totally 470 patients with aggregation inhibition test results (all 470 for clopidogrel and 464 for aspirin) were included in the study. Three hundred sixty-eight of them were male (78, 3%). The aspirin resistance group’s mean age was 60.8±10.3 years, the clopidogrel resistance group’s mean age was 58.89±10.1 years, and the aspirin + clopidogrel resistance group’s age was 63.25±8.8 years. Overall, there were 164 patients with single (either aspirin or clopidogrel) and 16 (3%) patients with double resistance. Hypertension, statin use, and platelet count were found as independent predictors of aspirin resistance. Hyperlipidemia, gender, and leucocyte count were found as independent predictors of clopidogrel resistance. Conclusion: 8.1% and 26.8% of stable CAD patients undergoing elective PCI showed insufficient aggregation inhibition by aspirin and clopidogrel, respectively, whereas 3% had double resistance.