Researcher:
Özsan, Çağrı

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Master Student

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Çağrı

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Özsan

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Özsan, Çağrı

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20221

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    Selective detection of carboxylesterase 2 activity in cancer cells using an activity-based chemiluminescent probe
    (Royal Soc Chemistry, 2022) Kailass, Karishma; Digby, Elyse M.; Beharry, Andrew A.; N/A; Department of Chemistry; Department of Chemistry; Özsan, Çağrı; Almammadov, Toghrul; Kölemen, Safacan; Master Student; Researcher; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); Koç University Boron and Advanced Materials Application and Research Center (KUBAM) / Koç Üniversitesi Bor ve İleri Malzemeler Uygulama ve Araştırma Merkezi (KUBAM); Graduate School of Sciences and Engineering; College of Sciences; College of Sciences; N/A; N/A; 272051
    Carboxylesterase 2 (CES2) has crucial roles in both xenobiotic metabolism and formation of pathogenic states including cancer. Thus, it is highly critical to monitor intracellular CES2 activity in living cancer cells. Here, we report a CES2 activatable phenoxy 1,2-dioxetane based chemiluminescent agent (CL-CES2). The probe exhibited a selective turn-on response in the presence of CES2 enzyme and enabled detection of CES2 activity in three different cancer cells that possess varying enzyme concentrations with high signal to noise ratios. In contrast no signal was obtained with CES1, an isoform of CES2 enzyme. CL-CES2 marks the first ever example of a CES2-responsive chemiluminescent luminophore and holds a great potential in further understanding the roles of CES2 activity in tumorogenesis.