Researcher:
Arbatlı, Semih

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PhD Student

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Semih

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Arbatlı

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Arbatlı, Semih

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2021 - 20223

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Researcher Of Publications: search.filters.isAuthorOfPublication.ea978ccf-f29e-46aa-b080-6048ab3a20cc

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    Identification of novel and potent modulators involved in neonatal cardiac regeneration (vol 42, pg 1554, 2021)
    (Springer, 2022) Aslan, Galip Servet; Polat, Feyza; Eren, Seyma Nur; Yucel, Dogacan; Cumbul, Alev; Kocabas, Fatih; N/A; Arbatlı, Semih; PhD Student; Graduate School of Health Sciences; N/A
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    Identification of novel and potent modulators involved in neonatal cardiac regeneration
    (Springer, 2021) Aslan, Galip Servet; Polat, Feyza; Eren, Seyma Nur; Yucel, Dogacan; Cumbul, Alev; Kocabas, Fatih; N/A; Arbatlı, Semih; PhD Student; Graduate School of Health Sciences; N/A
    Neonatal mammalian heart has been shown to possess the capacity to regenerate substantially after an injury. This remarkable regenerative capacity is lost in a week. This transition has been marked with cardiomyocyte cell cycle arrest and induction of fibrotic response similar to what occurs after myocardial infarction in adult hearts. Recent studies outlined the function of several cardiogenic factors that play a pivotal role in neonatal cardiac regeneration. However, underlying molecular mechanisms of neonatal cardiac regeneration and other cardiogenic factors remained elusive. Here, we investigated the involvement of novel putative cardiogenic factors in neonatal cardiac regeneration and cardiomyocyte cell cycle withdrawal. We have shown that Cbl, Dnmt3a, and Itch are significantly downregulated during neonatal cardiac regeneration process after cardiac injury in vivo. Intriguingly, several of studied factors are upregulated in non-regenerative period of 7-day-old mice after cardiac injury. Knockdown of Cbl, Dnmt3a and Itch in rat neonatal cardiomyocytes lead to the induction of cardiomyocyte proliferation. Cardiomyocyte proliferation accompanies upregulation of positive regulators of cardiomyocyte division and downregulation of CDKIs. Taken together, our findings suggest that Cbl, Dnmt3a, and Itch may be involved in the regulation of cardiomyocyte cell cycle withdrawal and may represent new targets for the induction of cardiac regeneration. GRAPHICAL ABSTRACT
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    PublicationOpen Access
    Effect of high-risk Obstructive sleep apnea on clinical outcomes in adults with Coronavirus Disease 2019: a multicenter, prospective, observational cohort study
    (American Thoracic Society (ATS), 2021) Işık, Sacide Rana; Balcan, Baran; Çetin, Betül; OSACOVID-19 Study Collaborators; Ertuğ, Elif; Peker, Yüksel; Çelik, Yeliz; Arbatlı, Semih; Baygül, Arzu Eden; Yazıcı, Duygu; Bayram, Hasan; Karataş, Ferhan; Uzel, Fatma Işıl; İliaz, Sinem; Tabak, Levent; Öztürk, Ayşe Bilge; Atasoy, Kayhan Çetin; Kapmaz, Mahir; Durmaz Çetin, Birsen; Çağlayan, Benan Niku; Faculty Member; Researcher; PhD Student; PhD Student; Faculty Member; Doctor; Doctor; Doctor; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Koç University Hospital; 234103; N/A; N/A; 272290; N/A; 4890; N/A; N/A; 168584; N/A; 147629; N/A; N/A; 111719; 230719
    Rationale: obstructive sleep apnea (OSA) may contribute to poor outcomes in adults with Coronavirus Disease 2019 (COVID-19). Objective: to determine the effect of OSA on clinical outcomes in patients with COVID-19. Methods: the current prospective observational study was conducted in three hospitals in Istanbul, Turkey from March 10 to June 22, 2020. The participants were categorized as modified high-risk (mHR), or low-risk (mLR)-OSA according to a modified version of the Berlin questionnaire. Snoring patterns (intensity and/or frequency), breathing pauses and morning/daytime sleepiness, without taking obesity and hypertension into account, were used in the regression models. Results: the primary outcome was clinical improvement defined as a decline of 2 categories from admission on a 7-category ordinal scale. Secondary outcomes included worsening (increase of 1 category), need for hospitalization, supplemental oxygen and intensive care. In total, 320 eligible patients were enrolled. According to the modified scoring, 70 (21.9%) had mHR-OSA. Among 242 patients requiring hospitalization, clinical improvement within 2 weeks occurred in 75.4 % of the mHR-OSA group compared to 88.4 % of the modified low-risk (mLR-OSA) group (P = 0.014). In multivariate regression analyses, mHR-OSA (adjusted OR 0.42; 95% CI 0.19-0.92) predicted the delayed clinical improvement. In the entire study population (n=320), mHR-OSA was associated with clinical worsening and need for supplemental oxygen. Snoring patterns, especially louder snoring, were significantly predicted delayed clinical improvement, worsening, need for hospitalization, supplemental oxygen, and intensive care. Conclusions: adults with mHR-OSA in our Covid-19 cohort had poorer clinical outcomes than those with mLR OSA independent of age, sex and comorbidities.