Researcher:
Giray, Seda

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Master Student

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Seda

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Giray

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Giray, Seda

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20121

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    Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system
    (Wiley, 2012) N/A; N/A; N/A; Department of Chemical and Biological Engineering; Department of Chemical and Biological Engineering; Giray, Seda; Bal, Tuğba; Kartal, Ayşe Meriç; Kızılel, Seda; Erkey, Can; Master Student; PhD Student; Master Student; Faculty Member; Faculty Member; Department of Chemical and Biological Engineering; N/A; N/A; N/A; College of Engineering; College of Engineering; N/A; 353534; N/A; 28376; 29633
    A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications. (C) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2012.