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Human transferrin detection through a mass-sensitive biosensor utilizing ZnO thin-films via atomic layer deposition

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Alev, Onur
Kilic, Alp
Coban, Muzeyyen
Buyukkose, Serkan
Ozturk, Selma
Ozturk, Zafer Z.

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en

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Abstract

In this letter, we present the first example of a zinc oxide (ZnO) thin film grown by atomic layer deposition method (ALD) on a quartz crystal microbalance (QCM) for the detection of human transferrin (hTF) molecule. Morphological, structural, and optical properties of ZnO thin film were investigated by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, ultraviolet-visible spectroscopy, and photoluminescence. For biosensor measurements, ZnO/QCM sensors were modified with antitransferrin to obtain selectivity against hTF. Mass-sensitive biosensor tests were carried out using two different measurement methods: dip-dry and flow-cell. It was observed that antitransferrin immobilized ZnO/QCM sensor detected hTF molecule in the range of 100-1000 ng. Moreover, the sensors exhibited better performance in the dip-dry method than the flow-cell method. ZnO-coated QCM exhibited good mass-sensitive performance, which make it a suitable sensor platform for biosensor applications.

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IEEE Sensors Letters

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Institute of Electrical and Electronics Engineers

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Engineering, electrical and electronic, Instruments and instrumentation, Physics, applied

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