Publication: Human transferrin detection through a mass-sensitive biosensor utilizing ZnO thin-films via atomic layer deposition
Program
KU-Authors
KU Authors
Co-Authors
Alev, Onur
Kilic, Alp
Coban, Muzeyyen
Buyukkose, Serkan
Ozturk, Selma
Ozturk, Zafer Z.
Advisor
Publication Date
Language
en
Type
Journal Title
Journal ISSN
Volume Title
Abstract
In this letter, we present the first example of a zinc oxide (ZnO) thin film grown by atomic layer deposition method (ALD) on a quartz crystal microbalance (QCM) for the detection of human transferrin (hTF) molecule. Morphological, structural, and optical properties of ZnO thin film were investigated by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, ultraviolet-visible spectroscopy, and photoluminescence. For biosensor measurements, ZnO/QCM sensors were modified with antitransferrin to obtain selectivity against hTF. Mass-sensitive biosensor tests were carried out using two different measurement methods: dip-dry and flow-cell. It was observed that antitransferrin immobilized ZnO/QCM sensor detected hTF molecule in the range of 100-1000 ng. Moreover, the sensors exhibited better performance in the dip-dry method than the flow-cell method. ZnO-coated QCM exhibited good mass-sensitive performance, which make it a suitable sensor platform for biosensor applications.
Description
Source:
IEEE Sensors Letters
Publisher:
Institute of Electrical and Electronics Engineers
Keywords:
Subject
Engineering, electrical and electronic, Instruments and instrumentation, Physics, applied