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Human transferrin detection through a mass-sensitive biosensor utilizing ZnO thin-films via atomic layer deposition

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dc.contributor.coauthorAlev, Onur
dc.contributor.coauthorKilic, Alp
dc.contributor.coauthorCoban, Muzeyyen
dc.contributor.coauthorBuyukkose, Serkan
dc.contributor.coauthorOzturk, Selma
dc.contributor.coauthorOzturk, Zafer Z.
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-12-29T09:40:15Z
dc.date.issued2024
dc.description.abstractIn this letter, we present the first example of a zinc oxide (ZnO) thin film grown by atomic layer deposition method (ALD) on a quartz crystal microbalance (QCM) for the detection of human transferrin (hTF) molecule. Morphological, structural, and optical properties of ZnO thin film were investigated by scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, X-ray diffraction spectroscopy, ultraviolet-visible spectroscopy, and photoluminescence. For biosensor measurements, ZnO/QCM sensors were modified with antitransferrin to obtain selectivity against hTF. Mass-sensitive biosensor tests were carried out using two different measurement methods: dip-dry and flow-cell. It was observed that antitransferrin immobilized ZnO/QCM sensor detected hTF molecule in the range of 100-1000 ng. Moreover, the sensors exhibited better performance in the dip-dry method than the flow-cell method. ZnO-coated QCM exhibited good mass-sensitive performance, which make it a suitable sensor platform for biosensor applications.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue7
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under Grant 120Z840. The authors would like to thank Prof. Dr.Mehmet Ali Ebeoglu and Asst. Prof. F & imath;rat Aydemir from Dumlupinar University for providing an optimized oscillator circuit.
dc.description.volume8
dc.identifier.doi10.1109/LSENS.2024.3414659
dc.identifier.issn2475-1472
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85196083992
dc.identifier.urihttps://doi.org/10.1109/LSENS.2024.3414659
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23273
dc.identifier.wos1256359800007
dc.keywordsMass sensors
dc.keywordsAtomic layer deposition (ALD)
dc.keywordsBiosensor
dc.keywordsHuman transferrin (hTF)
dc.keywordsQuartz crystal microbalance (QCM)
dc.keywordsZinc oxide (ZnO)
dc.language.isoeng
dc.publisherInstitute of Electrical and Electronics Engineers
dc.relation.ispartofIEEE Sensors Letters
dc.subjectEngineering, electrical and electronic
dc.subjectInstruments and instrumentation
dc.subjectPhysics, applied
dc.titleHuman transferrin detection through a mass-sensitive biosensor utilizing ZnO thin-films via atomic layer deposition
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTokyay, Begüm Kübra
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit2Graduate School of Sciences and Engineering
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