Publication:
Impact of weight change on kidney transplantation outcomes: A systematic review and meta-analysis

dc.contributor.coauthorSiriopol D., Mahmoud Abdel-Rahman S., Tuttle K.R.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorGüldan, Mustafa
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.kuauthorÖzbek, Laşin
dc.contributor.kuauthorYılmaz, Zeynep Yağmur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:58:05Z
dc.date.issued2024
dc.description.abstractBackground and Aim: Kidney transplant recipients frequently experience a wide range of metabolic complications, including weight changes, which significantly impact patient outcomes and graft function, yet the relationship between weight gain and transplant outcomes remains poorly understood. This systematic review and meta-analysis aimed to synthesise existing evidence on the influence of weight gain on patient and graft outcomes following kidney transplantation to enhance clinical practice and optimise post-transplant care strategies. Materials and Methods: A literature search was conducted across databases such as PubMed and Scopus for peer-reviewed studies published up to 8 August 2024. We included adult kidney transplant recipients (ages 18 years and older) with substantial and clinically relevant post-transplant weight gain and a control group without such changes, focusing on outcomes including all-cause mortality, graft survival, cardiovascular events and acute rejection. Results: The pooled analysis, which included data from 11 studies, indicated no significant association between post-transplant weight gain and the risk of all-cause mortality (hazard ratio [HR] 1.21, 95% confidence interval [CI] 0.69 to 2.10, p = 0.51;I2 = 28%), cardiovascular events (HR 0.93, 95% CI 0.43 to 2.01, p = 0.85;I2 = 32%) or acute rejection (HR 1.13, 95% CI 0.76 to 1.68, p = 0.55;I2 = 9%). However, weight gain was significantly associated with an increased risk of graft failure (HR 1.58, 95% CI 1.22 to 2.05, p andlt;0.001;I2 = 0%). Conclusion: Substantial and clinically relevant weight gain after kidney transplant was associated with a higher risk of graft failure. Within the timeframes of study observation, risks of all-cause mortality, cardiovascular events or acute rejection were not increased by weight gain in kidney transplant recipients. © 2024 John Wiley and Sons Ltd.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipKRT is supported by NIH research grants R01MD014712, U2CDK114886, UL1TR002319, U54DK083912, U01DK100846, OT2HL161847, UM1AI109568 and OT2OD032581 and CDC project numbers 75D301\u201021\u2010P\u201012254 and 75D301\u201023\u2010C\u201018264. She has also received investigator\u2010initiated grant support from Travere Therapeutics Inc., Bayer, Benaroya Research Institute and the Doris Duke Charitable Foundation. She reports consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Travere Therapeutics Inc., ProKidney and Pfizer and speaker fees from Novo Nordisk. Other authors have nothing to disclose.
dc.identifier.doi10.1111/dom.16135
dc.identifier.grantnoDoris Duke Charitable Foundation, DDCF; Travere Therapeutics; Bayer; National Institutes of Health, NIH: OT2OD032581, U54DK083912, UM1AI109568, UL1TR002319, R01MD014712, U01DK100846, OT2HL161847, U2CDK114886; National Institutes of Health, NIH; Centers for Disease Control and Prevention, CDC: 75D301‐21‐P‐12254, 75D301‐23‐C‐18264; Centers for Disease Control and Prevention, CDC
dc.identifier.issn1462-8902
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85212293631
dc.identifier.urihttps://doi.org/10.1111/dom.16135
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27356
dc.identifier.wos1380558300001
dc.keywordsAcute rejection
dc.keywordsCardiovascular event
dc.keywordsGraft failure
dc.keywordsPosttransplant weight gain
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofDiabetes, Obesity and Metabolism
dc.subjectMedicine
dc.titleImpact of weight change on kidney transplantation outcomes: A systematic review and meta-analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorGüldan, Mustafa
local.contributor.kuauthorÖzbek, Laşin
local.contributor.kuauthorYılmaz, Zeynep Yağmur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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