Publication:
Eosinophilic cationic protein and D-Dimer are potential biomarkers to predict response to antihistamines but not to omalizumab in chronic spontaneous urticaria

dc.contributor.coauthorAtik, Ozge
dc.contributor.coauthorTepetam, Fatma Merve
dc.contributor.coauthorOzden, Seyma
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKocatürk Göncü, Özgür Emek
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:59:26Z
dc.date.issued2024
dc.description.abstractIntroduction: Biomarkers that could reliably anticipate the effectiveness of antihistamines and omalizumab in treating chronic spontaneous urticaria (CSU) have not been conclusively identified. Our objective was to examine how eosinophilic cationic protein (ECP), tryptase, D-dimer, and total Immunoglobulin E (IgE) impact the response to antihistamine and omalizumab treatments in individuals with CSU. Methods: In this cross-sectional retrospective study, CSU patients that had undergone treatment with either antihistamines or omalizumab for a minimum of 12 weeks between 2015 and 2021 at an Allergy and Immunology Department were analyzed. Several demographic and laboratory parameters including eosinophil counts, mean platelet vol and uuml;me (MPV), sedimentation, C-reactive protein (CRP), antinuclear antibodies (ANA) and Anti-thyroperoxidase (Anti-TPO) and total IgE, tryptase, ECP and D-dimer were retrived from patient files. The association of these biomarkers with Urticaria Control Test (UCT) and the effect of these biomarkers on treatment response were evaluated. Treatment response was assessed using the UCT, with a score of UCT >= 12 indicating a responder and UCT < 12 indicating a non responder. Results: The patients in the omalizumab group were older, had a longer disease duration and had worse urticaria control (lower baseline UCT scores). 421 patients were treated with antihistamines and 88 patients were treated with omalizumab. ECP was found to be inversely correlated with baseline UCT (p < 0.001 r=-0.268). ECP and D-dimer levels of non-responder patients in the antihistamine group were significantly higher than in responder patients (ECP: 49 ng/mL vs 28.1 ng/mL, p < 0.001) (D-dimer: 0.60 mg/L vs 0.30 mg/L, p < 0.001), while there were no significant difference in terms of tryptase and total IgE. These four biomarkers were similar, in omalizumab responders and non responders. Conclusion: In this study with CSU, we looked at predictors of responses to treatments. ECP can serve as a marker of poor urticaria control and may predict antihistamine refractoriness along with D-dimer.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1080/19932820.2024.2420483
dc.identifier.eissn1819-6357
dc.identifier.issn1993-2820
dc.identifier.issue1
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85208073204
dc.identifier.urihttps://doi.org/10.1080/19932820.2024.2420483
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27704
dc.identifier.volume19
dc.identifier.wos1344512000001
dc.keywordsTryptase
dc.keywordsTreatment
dc.keywordsOmalizumab
dc.keywordsAntihistamines
dc.keywordsEosinophilic cationic protein
dc.keywordsD-dimer
dc.language.isoeng
dc.publisherTaylor and Francis
dc.relation.ispartofLibyan Journal of Medicine
dc.subjectMedicine
dc.titleEosinophilic cationic protein and D-Dimer are potential biomarkers to predict response to antihistamines but not to omalizumab in chronic spontaneous urticaria
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKocatürk Göncü, Özgür Emek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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