Publication: The photolyase/cryptochrome family of proteins as DNA repair enzymes and transcriptional repressors
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Program
KU Authors
Co-Authors
Aydın, Cihan
Advisor
Publication Date
2017
Language
English
Type
Journal Article
Journal Title
Journal ISSN
Volume Title
Abstract
Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors that perform different functions in different organisms. Photolyases repair ultraviolet-induced DNA damage by a process known as photoreactivation using photons absorbed from the blue end of the light spectrum. On the other hand, cryptochromes act as blue light circadian photoreceptors in plants and Drosophila to regulate growth and development. In mammals, cryptochromes have light-independent functions and are very important transcriptional regulators that act at the molecular level as negative transcriptional regulators of the circadian clock. In this review, we highlight current knowledge concerning the structural and functional relationships of CPF members.
Description
Source:
Photochemistry and Photobiology
Publisher:
Wiley
Keywords:
Subject
Biochemistry and molecular Biology, Biophysics