Publication:
Selenophene-modified boron dipyrromethene-based photosensitizers exhibit photodynamic inhibition on a broad range of bacteria

dc.contributor.coauthorÖzketen, Ahmet Çağlar
dc.contributor.coauthorKaraman, Osman
dc.contributor.coauthorÖzdemir, Alara
dc.contributor.coauthorSoysal, Işıl
dc.contributor.coauthorKızılenis, Çağlayan
dc.contributor.coauthorNteli Chatzioglou, Aisegkioul
dc.contributor.coauthorÇiçek, Yağız Anıl
dc.contributor.coauthorGünbaş, Görkem
dc.contributor.departmentDepartment of Chemistry
dc.contributor.kuauthorKölemen, Safacan
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.date.accessioned2024-11-09T12:39:53Z
dc.date.issued2022
dc.description.abstractMicroorganisms are crucial for human survival in view of both mutualistic and pathogen interactions. The control of the balance could be achieved by use of the antibiotics. There is a continuous arms race that exists between the pathogen and the antibiotics. The emergence of multidrug-resistant (MDR) bacteria threatens health even for insignificant injuries. However, the discovery of new antibiotics is not a fast process, and the healthcare system will suffer if the evolution of MDR lingers in its current frequency. The cationic photosensitizers (PSs) provide a unique approach to develop novel, light-inducible antimicrobial drugs. Here, we examine the antimicrobial activity of innovative selenophene-modified boron dipyrromethene (BODIPY)-based PSs on a variety of Gram (+) and Gram (-) bacteria. The candidates demonstrate a level of confidence in both light-dependent and independent inhibition of bacterial growth. Among them, selenophene conjugated PS candidates (BOD-Se and BOD-Se-I) are promising agents to induce photodynamic inhibition (PDI) on all experimented bacteria: E. coli, S. aureus, B. cereus, and P. aeruginosa. Further characterizations revealed that photocleavage ability on DNA molecules could be potentially advantageous over extracellular DNA possessing biofilm-forming bacteria such as B. cereus and P. aeruginosa. Microscopy analysis with fluorescent BOD-H confirmed the colocalization on GFP expressing E. coli.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue38
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume7
dc.identifier.doi10.1021/acsomega.2c02868
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03988
dc.identifier.issn2470-1343
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85139097153
dc.identifier.urihttps://doi.org/10.1021/acsomega.2c02868
dc.identifier.wos864460100001
dc.keywordsSelenium nanoparticles
dc.keywordsBodipy dyes
dc.keywordsIn-Vitro
dc.keywordsTherapy
dc.keywordsPhotoinactivation
dc.keywordsInactivation
dc.keywordsInfections
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.grantnoNA
dc.relation.ispartofACS Omega
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10864
dc.subjectChemistry
dc.titleSelenophene-modified boron dipyrromethene-based photosensitizers exhibit photodynamic inhibition on a broad range of bacteria
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKölemen, Safacan
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Chemistry
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relation.isOrgUnitOfPublication.latestForDiscovery035d8150-86c9-4107-af16-a6f0a4d538eb
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