Publication: Selenophene-modified boron dipyrromethene-based photosensitizers exhibit photodynamic inhibition on a broad range of bacteria
dc.contributor.coauthor | Özketen, Ahmet Çağlar | |
dc.contributor.coauthor | Karaman, Osman | |
dc.contributor.coauthor | Özdemir, Alara | |
dc.contributor.coauthor | Soysal, Işıl | |
dc.contributor.coauthor | Kızılenis, Çağlayan | |
dc.contributor.coauthor | Nteli Chatzioglou, Aisegkioul | |
dc.contributor.coauthor | Çiçek, Yağız Anıl | |
dc.contributor.coauthor | Günbaş, Görkem | |
dc.contributor.department | Department of Chemistry | |
dc.contributor.kuauthor | Kölemen, Safacan | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.date.accessioned | 2024-11-09T12:39:53Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Microorganisms are crucial for human survival in view of both mutualistic and pathogen interactions. The control of the balance could be achieved by use of the antibiotics. There is a continuous arms race that exists between the pathogen and the antibiotics. The emergence of multidrug-resistant (MDR) bacteria threatens health even for insignificant injuries. However, the discovery of new antibiotics is not a fast process, and the healthcare system will suffer if the evolution of MDR lingers in its current frequency. The cationic photosensitizers (PSs) provide a unique approach to develop novel, light-inducible antimicrobial drugs. Here, we examine the antimicrobial activity of innovative selenophene-modified boron dipyrromethene (BODIPY)-based PSs on a variety of Gram (+) and Gram (-) bacteria. The candidates demonstrate a level of confidence in both light-dependent and independent inhibition of bacterial growth. Among them, selenophene conjugated PS candidates (BOD-Se and BOD-Se-I) are promising agents to induce photodynamic inhibition (PDI) on all experimented bacteria: E. coli, S. aureus, B. cereus, and P. aeruginosa. Further characterizations revealed that photocleavage ability on DNA molecules could be potentially advantageous over extracellular DNA possessing biofilm-forming bacteria such as B. cereus and P. aeruginosa. Microscopy analysis with fluorescent BOD-H confirmed the colocalization on GFP expressing E. coli. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 38 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | N/A | |
dc.description.version | Publisher version | |
dc.description.volume | 7 | |
dc.identifier.doi | 10.1021/acsomega.2c02868 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR03988 | |
dc.identifier.issn | 2470-1343 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85139097153 | |
dc.identifier.uri | https://doi.org/10.1021/acsomega.2c02868 | |
dc.identifier.wos | 864460100001 | |
dc.keywords | Selenium nanoparticles | |
dc.keywords | Bodipy dyes | |
dc.keywords | In-Vitro | |
dc.keywords | Therapy | |
dc.keywords | Photoinactivation | |
dc.keywords | Inactivation | |
dc.keywords | Infections | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.relation.grantno | NA | |
dc.relation.ispartof | ACS Omega | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10864 | |
dc.subject | Chemistry | |
dc.title | Selenophene-modified boron dipyrromethene-based photosensitizers exhibit photodynamic inhibition on a broad range of bacteria | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Kölemen, Safacan | |
local.publication.orgunit1 | College of Sciences | |
local.publication.orgunit2 | Department of Chemistry | |
relation.isOrgUnitOfPublication | 035d8150-86c9-4107-af16-a6f0a4d538eb | |
relation.isOrgUnitOfPublication.latestForDiscovery | 035d8150-86c9-4107-af16-a6f0a4d538eb | |
relation.isParentOrgUnitOfPublication | af0395b0-7219-4165-a909-7016fa30932d | |
relation.isParentOrgUnitOfPublication.latestForDiscovery | af0395b0-7219-4165-a909-7016fa30932d |
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