Publication: Erythropoietin mediates brain-vascular-kidney crosstalk and may be a treatment target for pulmonary and resistant essential hypertension
Program
KU Authors
Co-Authors
Afsar, Baris
Publication Date
Language
Type
Embargo Status
Journal Title
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Volume Title
Alternative Title
Abstract
Organ crosstalk pathways represent the next frontier for target-mining in molecular medicine for existing syndromes. Pulmonary hypertension and resistant essential hypertension are syndromes that have been proven elusive in etiology, and frequently refractory to first-line management. Underlying crosstalk mechanisms, not yet considered in these treatments, may hinder outcomes or unlock novel treatments. This review focuses systematically on erythropoietin, a synthesizable molecule, as a mediator of brain-kidney crosstalk. Insights gained from this review will be applied to cardiovascular diseases in a clinician-directed fashion.
Source
Publisher
Taylor & Francis
Subject
Pharmacology, Pharmacy, Peripheral vascular disease
Citation
Has Part
Source
Clinical and Experimental Hypertension
Book Series Title
Edition
DOI
10.1080/10641963.2016.1246565