Publication: Safety of proton pump inhibitors in pediatric population: a systematic review
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Alla, Deekshitha
Shah, Dhruv Jayeshkumar
Seepana, Muneesh
Salian, Rishabh Baskara
Alla, Sai Santhosha Mrudula
Krishna Mohanan, Midhun
Vegesna, Mohan Sai Sunith
Singh, Aradhya
Gupta, Srajan
Shivalingappa Rekha, Shushrutha
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Objective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.
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Global Pediatric Health
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DOI
10.1177/2333794X241248967