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Safety of proton pump inhibitors in pediatric population: a systematic review

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dc.contributor.coauthorAlla, Deekshitha
dc.contributor.coauthorShah, Dhruv Jayeshkumar
dc.contributor.coauthorSeepana, Muneesh
dc.contributor.coauthorSalian, Rishabh Baskara
dc.contributor.coauthorAlla, Sai Santhosha Mrudula
dc.contributor.coauthorKrishna Mohanan, Midhun
dc.contributor.coauthorVegesna, Mohan Sai Sunith
dc.contributor.coauthorSingh, Aradhya
dc.contributor.coauthorGupta, Srajan
dc.contributor.coauthorShivalingappa Rekha, Shushrutha
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSabıroğlu, Mert
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:37:37Z
dc.date.issued2024
dc.description.abstractObjective. Commonly recommended drugs for adults and children include proton pump inhibitors (PPIs), proven effective for treating peptic diseases like stomach ulcers, GERD, and Helicobacter pylori infections in children over 1-year-old. Yet, prolonged PPI use carries higher risks of adverse reactions, prompting this study's analysis. Methods. We have performed a systematic review of 30 articles, which include a total of 762 505 pediatric patients. Results. Adverse effects were encountered in 6.98% of the population. The 5 most common adverse effects were respiratory tract complications, gastrointestinal complications, urinary tract infections, asthma, and ENT infections. Conclusion. Hence, PPIs should be prescribed only when necessary, and physicians should prioritize patient education when considering their use.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessgold
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume11
dc.identifier.doi10.1177/2333794X241248967
dc.identifier.eissn2333-794X
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85192367577
dc.identifier.urihttps://doi.org/10.1177/2333794X241248967
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22424
dc.identifier.wos1209279100001
dc.keywordsProton pump inhibitors
dc.keywordsPediatric population
dc.keywordsGI infections
dc.keywordsSecondary infections
dc.keywordsAdverse effects
dc.language.isoeng
dc.publisherSAGE
dc.relation.ispartofGlobal Pediatric Health
dc.subjectPediatrics
dc.titleSafety of proton pump inhibitors in pediatric population: a systematic review
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorSabıroğlu, Mert
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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