Publication: Novel index combining Pan-Immune-Inflammatory index and hemoglobin levels (PIV/HB) predicts trismus rates efficiently after chemoradiotherapy in locally advanced nasopharyngeal cancer
Program
School / College / Institute
SCHOOL OF MEDICINE
KU-Authors
KU Authors
Co-Authors
Somay, Efsun
Yilmaz, Busra
Topkan, Erkan
Ozdemir, Beyza Sirin
Ozturk, Duriye
Besen, Ali Ayberk
Mertsoylu, Huseyin
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Embargo Status
Journal Title
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Abstract
Purpose. To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT). Methods. Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs <= 35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis. Results. Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%;specificity: 86.4%;sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%;P<0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT. Conclusion. Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs.
Source
Publisher
Wiley
Subject
Oncology
Citation
Has Part
Source
INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY
Book Series Title
Edition
DOI
10.1155/2024/2124006