Publication: Novel index combining Pan-Immune-Inflammatory index and hemoglobin levels (PIV/HB) predicts trismus rates efficiently after chemoradiotherapy in locally advanced nasopharyngeal cancer
dc.contributor.coauthor | Somay, Efsun | |
dc.contributor.coauthor | Yilmaz, Busra | |
dc.contributor.coauthor | Topkan, Erkan | |
dc.contributor.coauthor | Ozdemir, Beyza Sirin | |
dc.contributor.coauthor | Ozturk, Duriye | |
dc.contributor.coauthor | Besen, Ali Ayberk | |
dc.contributor.coauthor | Mertsoylu, Huseyin | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Selek, Uğur | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-03-06T20:58:45Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Purpose. To evaluate the predictive potency of a novel index combining the pan-immune-inflammatory index and hemoglobin levels (PIV/Hb) for the prevalence of radiation-induced trismus (RIT) in patients with locally advanced nasopharyngeal cancer (LA-NPC) receiving concurrent chemoradiotherapy (CCRT). Methods. Data from 228 LA-NPC patients were retrospectively examined. Maximum mouth openings (MMO) were measured to confirm the presence of RIT, defined as MMOs <= 35 mm. Complete blood test results from the first day of CCRT were used to calculate PIV/Hb levels. A potential relationship between pretreatment PIV/Hb and the RIT status was evaluated using receiver operating characteristic (ROC) curve analysis. Results. Post-CCRT RIT was diagnosed in 20.2% of the patients. The ROC curve analysis determined 68.4 g/dL as the ideal PIV/Hb cutoff that effectively divided patients into two distinct groups (area under the curve: 94.7%;specificity: 86.4%;sensitivity: 87.4%). RIT was significantly more prevalent in the PIV/Hb > 68 group than in the PIV/Hb < 68 group (58.8% vs. 3.8%;P<0.001). Multivariate logistic regression analysis showed that a pre-CCRT PIV > 68 was independently associated with significantly higher rates of RIT. Conclusion. Higher pretreatment levels of the novel PIV/Hb index predict increased RIT rates following definitive CCRT for LA-NPCs. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.identifier.doi | 10.1155/2024/2124006 | |
dc.identifier.eissn | 2090-1410 | |
dc.identifier.issn | 2090-1402 | |
dc.identifier.quartile | Q4 | |
dc.identifier.scopus | 2-s2.0-85205781100 | |
dc.identifier.uri | https://doi.org/10.1155/2024/2124006 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/27551 | |
dc.identifier.volume | 2024 | |
dc.identifier.wos | 1336561400001 | |
dc.keywords | PIV/Hb index | |
dc.keywords | Radiation-induced trismus | |
dc.keywords | Nasopharyngeal cancer | |
dc.keywords | Chemoradiotherapy | |
dc.keywords | Pretreatment levels | |
dc.keywords | Predictive index | |
dc.keywords | Receiver operating characteristic analysis | |
dc.keywords | Multivariate logistic regression | |
dc.keywords | Maximum mouth opening | |
dc.keywords | Trismus prevalence | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF SURGICAL ONCOLOGY | |
dc.subject | Oncology | |
dc.title | Novel index combining Pan-Immune-Inflammatory index and hemoglobin levels (PIV/HB) predicts trismus rates efficiently after chemoradiotherapy in locally advanced nasopharyngeal cancer | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Selek, Uğur | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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