Publication: Transitional outcomes of adults who underwent Cohen ureteroneocystostomy for the treatment of vesicoureteral reflux as children
dc.contributor.coauthor | Selvi I., İrfan Dönmez M., Gürcan M., Aydınoğlu A.T., Ziylan O. | |
dc.contributor.department | KUH (Koç University Hospital) | |
dc.contributor.kuauthor | Oktar, Tayfun | |
dc.contributor.schoolcollegeinstitute | KUH (KOÇ UNIVERSITY HOSPITAL) | |
dc.date.accessioned | 2025-03-06T21:01:29Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Objective: To analyze the transitional outcomes of children who underwent Cohen ureteroneocystostomy(UNC) due to vesicoureteral reflux(VUR). Methods: Files of patients who underwent UNC between January 2003 and December 2013 and had >10 years of follow-up were retrospectively reviewed. Demographic and clinical data before surgery were noted. Lower urinary tract dysfunction (LUTD) status was assessed via ICIQ M/F-LUTS, voiding diary and uroflowmetry in all patients. Renal functions, hypertension, proteinuria, febrile/afebrile urinary tract infections(UTIs), and complications associated with pregnancy were noted. Results: Two hundred and forty-one patients (140 girls, 58.1%) underwent UNC at a median age of 6.5 years (3-14), and 57.7% underwent bilateral surgery. After a median follow-up of 15 years (10-20), median patient age at the last clinic visit was 21 years (18-31). LUTD was detected in 69 (28.6%) patients. Bilateral disease, female gender, history of childhood bladder bowel dysfunction(BBD), presence of renal scar, and older age (≥7 years) at the time of surgery were significantly associated with LUTD in adulthood. Febrile UTI was detected in 7.9% (19/241) following UNC, whereas 6 needed subureteral injection due to persistent low-grade VUR. No patient developed stage 3 or greater chronic kidney disease, but 11(4.6%) patients developed hypertension and 7(2.9%) had proteinuria. Of 67 sexually active female patients,10(14.9%) had febrile UTIs. Of 49 women in whom pregnancy was observed,4(8.1%) had febrile UTIs, 7(14.2%) had afebrile UTIs and 2(4.1%) had pre-eclampsia during pregnancy, but none had a miscarriage or early labor. Conclusion: Despite VUR control, the incidence of febrile UTI and pre-eclampsia during pregnancy should not be underestimated. In addition, a quarter of patients face LUTD when they reach adulthood. Female patients with bilateral disease, renal scar, and previous childhood BBD have higher risks for these transitional clinical problems. | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.identifier.doi | 10.1016/j.urology.2024.12.006 | |
dc.identifier.eissn | 1527-9995 | |
dc.identifier.issn | 0090-4295 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85213230601 | |
dc.identifier.uri | https://doi.org/10.1016/j.urolonc.2024.10.019 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/27991 | |
dc.keywords | Transitional outcomes | |
dc.keywords | Cohen ureteroneocystostomy | |
dc.keywords | Vesicoureteral reflux | |
dc.keywords | Pediatric urology | |
dc.keywords | Long-term follow-up | |
dc.keywords | Urinary tract reconstruction | |
dc.language.iso | eng | |
dc.publisher | Elsevier Inc. | |
dc.relation.ispartof | Urology | |
dc.subject | Urology and nephrology | |
dc.title | Transitional outcomes of adults who underwent Cohen ureteroneocystostomy for the treatment of vesicoureteral reflux as children | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Oktar, Tayfun | |
local.publication.orgunit1 | KUH (KOÇ UNIVERSITY HOSPITAL) | |
local.publication.orgunit2 | KUH (Koç University Hospital) | |
relation.isOrgUnitOfPublication | f91d21f0-6b13-46ce-939a-db68e4c8d2ab | |
relation.isOrgUnitOfPublication.latestForDiscovery | f91d21f0-6b13-46ce-939a-db68e4c8d2ab | |
relation.isParentOrgUnitOfPublication | 055775c9-9efe-43ec-814f-f6d771fa6dee | |
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