Publication:
Generation of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2

Simple item page
dc.contributor.coauthorZeng, Ruizhu
dc.contributor.coauthorSidik, Harwin
dc.contributor.coauthorRobinson, Kim S.
dc.contributor.coauthorZhong, Franklin L.
dc.contributor.coauthorPouladiahi, Mahmoud A.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorReversade, Bruno
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T11:44:31Z
dc.date.issued2019
dc.description.abstractRett syndrome (RTT) is a childhood neurodevelopmental disorder caused by mutations in MECP2. To study the molecular mechanisms underlying RTT, four sublines of H1 hESCs were generated, carrying a hemizygous knockout or mutant allele of MECP2. Exons 3 and 4 of MECP2 were targeted using the CRISPR/Cas9 nuclease system.
dc.description.fulltextYES
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipStrategic Positioning Fund for Genetic Orphan Diseases
dc.description.sponsorshipSUREKids from the Agency for Science Technology and Research (Singapore)
dc.description.sponsorshipTLGM-NDD from Agency for Science Technology and Research (Singapore)
dc.description.sponsorshipthe National University of Singapore
dc.description.versionPublisher version
dc.description.volume40
dc.identifier.doi10.1016/j.scr.2019.101533
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01621
dc.identifier.issn1873-5061
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85070998455
dc.identifier.urihttps://doi.org/10.1016/j.scr.2019.101533
dc.keywordsRett syndrome
dc.keywordsMethyl-CpG-binding protein 2
dc.keywordsMutation
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantnoSPF2012/005
dc.relation.grantnoIAF311019
dc.relation.ispartofStem Cell Research
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8234
dc.subjectMedicine
dc.titleGeneration of four H1 hESC sublines carrying a hemizygous knock-out/mutant MECP2
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorReversade, Bruno
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
8234.pdf
Size:
1.05 MB
Format:
Adobe Portable Document Format
Download

Collections

Publications with Fulltext