Publication: Discovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design
Program
KU Authors
Co-Authors
Advisor
Publication Date
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Abstract
It has been shown that prostate cancer is associated with elevated androgen biosynthesis; therefore, inhibiting the activity of Cytochrome P450 17 (CYP17) may prevent progression of prostate cancer. In this study we identified, using in silico and experimental methods, two novel steroidal and non-steroidal lead compounds that inhibit the activity CYP17.
Source:
Letters In Drug Design & Discovery
Publisher:
Bentham Science Publ Ltd
Keywords:
Subject
Chemistry, Medicinal