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Discovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design

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dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentDepartment of Industrial Engineering
dc.contributor.facultymemberYes
dc.contributor.kuauthorArmutlu, Pelin
dc.contributor.kuauthorKavaklı, İbrahim Halil
dc.contributor.kuauthorÖzdaş, Şule Beyhan
dc.contributor.kuauthorÖzdemir, Muhittin Emre
dc.contributor.kuauthorTürkay, Metin
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T23:57:32Z
dc.date.issued2009
dc.description.abstractIt has been shown that prostate cancer is associated with elevated androgen biosynthesis; therefore, inhibiting the activity of Cytochrome P450 17 (CYP17) may prevent progression of prostate cancer. In this study we identified, using in silico and experimental methods, two novel steroidal and non-steroidal lead compounds that inhibit the activity CYP17.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessNO
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipTurkish Academy of Science (TÜBA)
dc.description.studentonlypublicationNo
dc.description.studentpublicationYes
dc.description.versionN/A
dc.identifier.WoSQuartileQ4
dc.identifier.doi10.2174/1570180810906050337
dc.identifier.eissn1875-628X
dc.identifier.embargoN/A
dc.identifier.endpage344
dc.identifier.issn1570-1808
dc.identifier.issue5
dc.identifier.scopus2-s2.0-67650555893
dc.identifier.startpage337
dc.identifier.urihttps://doi.org/10.2174/1570180810906050337
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15313
dc.identifier.volume6
dc.identifier.wos000268218000004
dc.keywordsProstate cancer
dc.keywordsAndrogen biosynthesis
dc.keywordsCytochrome P450 enzyme 17r-hydroxylase-17
dc.keywords20-Lyase
dc.keywordsVirtual screening
dc.language.isoeng
dc.publisherBentham Science Publishers
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofLetters in Drug Design and Discovery
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectChemistry
dc.titleDiscovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorArmutlu, Pelin
local.contributor.kuauthorÖzdemir, Muhittin Emre
local.contributor.kuauthorÖzdaş, Şule Beyhan
local.contributor.kuauthorKavaklı, İbrahim Halil
local.contributor.kuauthorTürkay, Metin
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relation.isOrgUnitOfPublicationd6d00f52-d22d-4653-99e7-863efcd47b4a
relation.isOrgUnitOfPublication.latestForDiscoveryc747a256-6e0c-4969-b1bf-3b9f2f674289
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

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