Publication: Discovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design
dc.contributor.department | Department of Chemical and Biological Engineering | |
dc.contributor.department | Department of Industrial Engineering | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.kuauthor | Armutlu, Pelin | |
dc.contributor.kuauthor | Kavaklı, İbrahim Halil | |
dc.contributor.kuauthor | Özdaş, Şule Beyhan | |
dc.contributor.kuauthor | Özdemir, Muhittin Emre | |
dc.contributor.kuauthor | Türkay, Metin | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.date.accessioned | 2024-11-09T23:57:32Z | |
dc.date.issued | 2009 | |
dc.description.abstract | It has been shown that prostate cancer is associated with elevated androgen biosynthesis; therefore, inhibiting the activity of Cytochrome P450 17 (CYP17) may prevent progression of prostate cancer. In this study we identified, using in silico and experimental methods, two novel steroidal and non-steroidal lead compounds that inhibit the activity CYP17. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.issue | 5 | |
dc.description.openaccess | NO | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Turkish Academy of Science Young Scholar Program (TUBA-GEBIP) We would like to thank Professor R. Auchus for kindly providing us cDNA of human CYP17. MT thanks IBM Corporation for providing computing hardware support through IBM SUR Award. IHK thanks the support from Turkish Academy of Science Young Scholar Program (TUBA-GEBIP). | |
dc.description.volume | 6 | |
dc.identifier.doi | 10.2174/1570180810906050337 | |
dc.identifier.eissn | 1875-628X | |
dc.identifier.issn | 1570-1808 | |
dc.identifier.scopus | 2-s2.0-67650555893 | |
dc.identifier.uri | https://doi.org/10.2174/1570180810906050337 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/15313 | |
dc.identifier.wos | 268218000004 | |
dc.keywords | Prostate cancer | |
dc.keywords | Androgen biosynthesis | |
dc.keywords | Cytochrome P450 enzyme 17r-hydroxylase-17 | |
dc.keywords | 20-Lyase | |
dc.keywords | Virtual screening | |
dc.keywords | Human P450c17 | |
dc.keywords | 3-beta-hydroxysteroid dehydrogenase | |
dc.keywords | Androgen synthesis | |
dc.keywords | In-vitro | |
dc.keywords | Thiazolidinediones | |
dc.keywords | Model | |
dc.language.iso | eng | |
dc.publisher | Bentham Science Publ Ltd | |
dc.relation.ispartof | Letters In Drug Design & Discovery | |
dc.subject | Chemistry | |
dc.subject | Medicinal | |
dc.title | Discovery of novel CYP17 inhibitors for the treatment of prostate cancer with structure-based drug design | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Armutlu, Pelin | |
local.contributor.kuauthor | Özdemir, Muhittin Emre | |
local.contributor.kuauthor | Özdaş, Şule Beyhan | |
local.contributor.kuauthor | Kavaklı, İbrahim Halil | |
local.contributor.kuauthor | Türkay, Metin | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit2 | Department of Chemical and Biological Engineering | |
local.publication.orgunit2 | Department of Industrial Engineering | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
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