Publication:
Assessment of the VENUSS and GRANT models for individual prediction of cancer-specific survival in surgically treated nonmetastatic papillary renal cell carcinoma

dc.contributor.coauthorPiccinelli, Mattia L.
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorGarcia, Cristina Cano
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorMorra, Simone
dc.contributor.coauthorScheipner, Lukas
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorLuzzago, Stefano
dc.contributor.coauthorMistretta, Francesco A.
dc.contributor.coauthorFerro, Matteo
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorAhyai, Sascha
dc.contributor.coauthorLongo, Nicola
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorChun, Felix K. H.
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorde Cobelli, Ottavio
dc.contributor.coauthorMusi, Gennaro
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:40:49Z
dc.date.issued2023
dc.description.abstractBackground: Guidelines recommend VENUSS and GRANT models for the prediction of cancer control outcomes after nephrectomy for nonmetastatic papillary renal cell carcinoma (pRCC).Objective: To test the ability of VENUSS and GRANT models to predict 5-yr cancer specific survival in a North American population.Design, setting, and participants: For this retrospective study, we identified 4184 patients with unilateral surgically treated nonmetastatic pRCC in the Surveillance, Epidemiology, and End Results database (2004-2019).Outcome measurements and statistical analysis: The original VENUSS and GRANT risk categories were applied to predict 5-yr cancer-specific survival. A cross-validation method was used to test the accuracy and calibration of the models and to conduct decision curve analyses for the study cohort.Results and limitations: The VENUSS and GRANT categories represented independent predictors of cancer-specific mortality. On cross-validation, the accuracy of the VENUSS and GRANT risk categories was 0.73 and 0.65, respectively. Both models showed good calibration and performed better than random predictions in decision curve analysis. Limitations include the retrospective nature of the study and the absence of a central pathological review.Conclusion: VENUSS risk categories fulfilled prognostic model criteria for predicting cancer-specific survival 5 yr after surgery in North American patients with non-metastatic pRCC as recommended by guidelines. Conversely, GRANT risk categories did not. Thus, VENUSS risk categories represent an important tool for counseling, follow-up planning, and patient selection for appropriate adjuvant trials in pRCC. Patient summary: We tested the ability of two validated methods (VENUSS and GRANT) to predict death due to papillary kidney cancer in a North American pop-ulation. The VENUSS risk categories showed good performance in predicting 5-year cancer-specific survival.& COPY; 2023 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology. This is an open access article under the CC BY-NC-ND license (http://creative-commons.org/licenses/by-nc-nd/4.0/).
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessgold, Green Published
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume53
dc.identifier.doi10.1016/j.euros.2023.05.005
dc.identifier.eissn2666-1683
dc.identifier.issn2666-1691
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85161860910
dc.identifier.urihttps://doi.org/10.1016/j.euros.2023.05.005
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23454
dc.identifier.wos1056459500001
dc.keywordsCancer-specific mortality
dc.keywordsPapillary kidney cancer
dc.keywordsPrognostic model
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofEuropean Urology Open Science
dc.subjectUrology
dc.subjectNephrology
dc.titleAssessment of the VENUSS and GRANT models for individual prediction of cancer-specific survival in surgically treated nonmetastatic papillary renal cell carcinoma
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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