Publication:
Spreading depolarization waves in neurological diseases: a short review about its pathophysiology and clinical relevance

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dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÖzdemir, Yasemin Gürsoy
dc.contributor.kuauthorSolaroğlu, İhsan
dc.contributor.kuauthorTaş, Yağmur Çetin
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:57:30Z
dc.date.issued2019
dc.description.abstractLesion growth following acutely injured brain tissue after stroke, subarachnoid hemorrhage and traumatic brain injury is an important issue and a new target area for promising therapeutic interventions. Spreading depolarization or peri-lesion depolarization waves were demonstrated as one of the significant contributors of continued lesion growth. In this short review, we discuss the pathophysiology for SD forming events and try to list findings detected in neurological disorders like migraine, stroke, subarachnoid hemorrhage and traumatic brain injury in both human as well as experimental studies. Pharmacological and non-pharmacological treatment strategies are highlighted and future directions and research limitations are discussed.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume17
dc.identifier.doi10.2174/1570159X15666170915160707
dc.identifier.eissn1875-6190
dc.identifier.issn1570-159X
dc.identifier.scopus2-s2.0-85060143320
dc.identifier.urihttps://doi.org/10.2174/1570159X15666170915160707
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15305
dc.identifier.wos458582200004
dc.keywordsSpreading depression
dc.keywordsPeri-infarct depolarization
dc.keywordsStroke
dc.keywordsSubarachnoid hemorrhage
dc.keywordsTraumatic brain injury
dc.keywordsMigraine
dc.language.isoeng
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Neuropharmacology
dc.subjectNeurosciences
dc.subjectPharmacology
dc.subjectPharmacy
dc.titleSpreading depolarization waves in neurological diseases: a short review about its pathophysiology and clinical relevance
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorTaş, Yağmur Çetin
local.contributor.kuauthorSolaroğlu, İhsan
local.contributor.kuauthorÖzdemir, Yasemin Gürsoy
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
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relation.isParentOrgUnitOfPublication.latestForDiscoveryd437580f-9309-4ecb-864a-4af58309d287

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