Publication: Design of bioartificial pancreas with functional micro/nano-based encapsulation of islets
Program
KU Authors
Co-Authors
N/A
Advisor
Publication Date
2014
Language
English
Type
Journal Article
Journal Title
Journal ISSN
Volume Title
Abstract
Type I diabetes mellitus (TIDM), a devastating health issue in all over the world, has been treated by successful transplantation of insulin secreting pancreatic islets. However, serious limitations such as the requirement of immunosuppressive drugs for recipient patients, side effects as a result of long-term use of drugs, and reduced functionality of islets at the transplantation site remain. Bioartificial pancreas that includes islets encapsulated within semi-permeable membrane has been considered as a promising approach to address these requirements. Many studies have focused on micro or nano-based islet immunoisolation systems and tested the efficacy of encapsulated islets using in vitro and in vivo platforms. In this review, we address current progress and obstacles for the development of a bioartificial pancreas using micro/nano-based systems for encapsulation of islets.
Description
Source:
Current Pharmaceutical Biotechnology
Publisher:
Bentham Science Publ Ltd
Keywords:
Subject
Biochemistry, Molecular biology, Pharmacology, Pharmacy