Publication:
The role of S100A12 and Toll-like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis

dc.contributor.coauthorDumur, Seyma
dc.contributor.coauthorBarut, Kenan
dc.contributor.coauthorKasapcopur, Ozgur
dc.contributor.coauthorKucur, Mine
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorYıldız, Amra Adrovic
dc.contributor.kuprofileDoctor
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.yokidN/A
dc.date.accessioned2024-11-09T23:36:39Z
dc.date.issued2023
dc.description.abstractObjective: Our aim was to investigate the possible relationship between the serum S100A12 and Toll-like receptor 4 (TLR4) levels, and the activity of familial Mediterranean fever (FMF) and juvenile idiopathic arthritis (JIA) in accordance with the routine biochemical parameters. Furthermore, the effectiveness of these 2 biomarkers in distinguishing FMF from JIA has been evaluated. Method: Sixty-nine children with FMF, 68 children with JIA, and 35 healthy children were included in this study. S100A12 and TLR4 levels were measured by the sandwich enzyme-linked immunosorbent assay technique. Results: In the FMF patient group, serum S100A12 level was found to be significantly higher than in both the JIA and control groups (P = .000 and P = .000, respectively). Although S100A12 levels were higher in the attack period compared to the attack-free period, this increase was not statistically significant (P > .05). TLR4 levels were statistically significantly higher in the attack period compared to the attack-free period in children with FMF (P < .05). Although there was no relationship between S100A12 levels and disease activity, there is a clear correlation between S100A12 and the Auto-Inflammatory Disease Activity Index in attack-free FMF patients (r = 0.612 P = .000). Conclusion: Serum S100A12 levels were not found to be a potentially valuable biomarker for assessing disease activity in either FMF or JIA. However, TLR4 levels were found to be a valuable biomarker for assessing disease activity in children with FMF. Further research which includes serial monitoring of S100A12 and TLR4 levels in a large cohort will provide detailed information about accuracy of these 2 potential biomarkers in both patients group.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessNO
dc.description.sponsorshipScientific Research Projects Coordination Unit (BAP) of Istanbul University-Cerrahpasa [34213] Scientific Research Projects Coordination Unit (BAP) of Istanbul University-Cerrahpasa, Grant/Award Number: 34213
dc.description.sponsorshipIstanbul Universitesi
dc.description.volume26
dc.identifier.doi10.1111/1756-185X.14475
dc.identifier.eissn1756-185X
dc.identifier.issn1756-1841
dc.identifier.scopus2-s2.0-85141350495
dc.identifier.urihttp://dx.doi.org/10.1111/1756-185X.14475
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12674
dc.identifier.wos874088400001
dc.keywordsDisease activity
dc.keywordsFamilial Mediterranean fever
dc.keywordsJuvenile idiopathic arthritis
dc.languageEnglish
dc.publisherWiley
dc.sourceInternational Journal Of Rheumatic Diseases
dc.subjectRheumatology
dc.titleThe role of S100A12 and Toll-like receptor 4 in assessment of disease activity in familial Mediterranean fever and juvenile idiopathic arthritis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.kuauthorYıldız, Amra Adrovic
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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