Publication: Shorter time to begin of QRS fragmentation predicts non-response to cardiac resynchronization therapy in non-ischemic heart failure patients
dc.contributor.coauthor | Celikyurt, U. | |
dc.contributor.coauthor | Açar, B. | |
dc.contributor.coauthor | Karauzum, I. | |
dc.contributor.coauthor | Karauzum, K. | |
dc.contributor.coauthor | Agir, A.A. | |
dc.contributor.coauthor | Vural A. | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Ural, Dilek | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2024-11-09T22:51:56Z | |
dc.date.issued | 2019 | |
dc.description.abstract | Objective: cardiac resynchronization therapy (CRT)is an effective option in the treatment of patients with heart failure and wide QRS. Presence of fragmented QRS (f-QRS)on 12-lead electrocardiogram (ECG)has been shown to be associated with non-response to CRT. The aim of this study was to evaluate whether onset of fragmentation (Q-f interval)is important for CRT response. Methods: this is a single-center retrospective analysis of prospectively collected data of 38 non-ischemic dilated cardiomyopathy patients (18 men, mean age 63 ± 12 years)with f-QRS on 12-lead ECG who underwent CRT. Duration of fragmentation, ratio of f-QRS duration to the total QRS duration (f-QRS/t-QRS ratio)and time interval from Q wave to the onset of QRS fragmentation (Q-f interval)were measured. Results: the baseline clinical, echocardiographic findings of patients with responders (24 patients, 63%)and non-responders showed no statistically significant difference, except for longer f-QRS duration, increased ratio of f-QRS duration to the total QRS duration (f-QRS/t-QRS ratio)and shorter time interval from Q wave to the onset of QRS fragmentation (Q-f interval)in patients not responding to CRT. In multivariate analysis, Q-f interval was determined as an independent predictor of response to CRT (OR 1.240, 95% CI: 1.049-1.467, P =.012). In ROC curve analysis, the best cut-off value for Q-f interval to predict responders was 32.5 ms with a sensitivity and specificity of 83.3% and 85.7%, respectively (AUC 0.899, 95% CI: 0.797-1.000, P =.001). Conclusions: shorter time from onset of QRS to beginning of fragmentation is a simple ECG marker to predict non-responsive patients to CRT. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 5 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.volume | 219 | |
dc.identifier.doi | 10.1016/j.rce.2018.11.008 | |
dc.identifier.issn | 0014-2565 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85060102924 | |
dc.identifier.uri | https://doi.org/10.1016/j.rce.2018.11.008 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/6939 | |
dc.keywords | Cardiac resynchronization therapy | |
dc.keywords | Response | |
dc.keywords | Fragmented QRS | |
dc.language.iso | eng | |
dc.language.iso | spa | |
dc.publisher | Elsevier | |
dc.relation.ispartof | Revista Clinica Espanola | |
dc.subject | General and internal medicine | |
dc.title | Shorter time to begin of QRS fragmentation predicts non-response to cardiac resynchronization therapy in non-ischemic heart failure patients | |
dc.title.alternative | El inicio rápido de la fragmentación del QRS predice la no respuesta a la terapia de resincronización cardíaca en pacientes con insuficiencia cardíaca no isquémica | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Ural, Dilek | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
relation.isOrgUnitOfPublication | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isOrgUnitOfPublication.latestForDiscovery | d02929e1-2a70-44f0-ae17-7819f587bedd | |
relation.isParentOrgUnitOfPublication | 17f2dc8e-6e54-4fa8-b5e0-d6415123a93e | |
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