Publication:
Shorter time to begin of QRS fragmentation predicts non-response to cardiac resynchronization therapy in non-ischemic heart failure patients

dc.contributor.coauthorCelikyurt, U.
dc.contributor.coauthorAçar, B.
dc.contributor.coauthorKarauzum, I.
dc.contributor.coauthorKarauzum, K.
dc.contributor.coauthorAgir, A.A.
dc.contributor.coauthorVural A.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorUral, Dilek
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:51:56Z
dc.date.issued2019
dc.description.abstractObjective: cardiac resynchronization therapy (CRT)is an effective option in the treatment of patients with heart failure and wide QRS. Presence of fragmented QRS (f-QRS)on 12-lead electrocardiogram (ECG)has been shown to be associated with non-response to CRT. The aim of this study was to evaluate whether onset of fragmentation (Q-f interval)is important for CRT response. Methods: this is a single-center retrospective analysis of prospectively collected data of 38 non-ischemic dilated cardiomyopathy patients (18 men, mean age 63 ± 12 years)with f-QRS on 12-lead ECG who underwent CRT. Duration of fragmentation, ratio of f-QRS duration to the total QRS duration (f-QRS/t-QRS ratio)and time interval from Q wave to the onset of QRS fragmentation (Q-f interval)were measured. Results: the baseline clinical, echocardiographic findings of patients with responders (24 patients, 63%)and non-responders showed no statistically significant difference, except for longer f-QRS duration, increased ratio of f-QRS duration to the total QRS duration (f-QRS/t-QRS ratio)and shorter time interval from Q wave to the onset of QRS fragmentation (Q-f interval)in patients not responding to CRT. In multivariate analysis, Q-f interval was determined as an independent predictor of response to CRT (OR 1.240, 95% CI: 1.049-1.467, P =.012). In ROC curve analysis, the best cut-off value for Q-f interval to predict responders was 32.5 ms with a sensitivity and specificity of 83.3% and 85.7%, respectively (AUC 0.899, 95% CI: 0.797-1.000, P =.001). Conclusions: shorter time from onset of QRS to beginning of fragmentation is a simple ECG marker to predict non-responsive patients to CRT.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume219
dc.identifier.doi10.1016/j.rce.2018.11.008
dc.identifier.issn0014-2565
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85060102924
dc.identifier.urihttps://doi.org/10.1016/j.rce.2018.11.008
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6939
dc.keywordsCardiac resynchronization therapy
dc.keywordsResponse
dc.keywordsFragmented QRS
dc.language.isoeng
dc.language.isospa
dc.publisherElsevier
dc.relation.ispartofRevista Clinica Espanola
dc.subjectGeneral and internal medicine
dc.titleShorter time to begin of QRS fragmentation predicts non-response to cardiac resynchronization therapy in non-ischemic heart failure patients
dc.title.alternativeEl inicio rápido de la fragmentación del QRS predice la no respuesta a la terapia de resincronización cardíaca en pacientes con insuficiencia cardíaca no isquémica
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorUral, Dilek
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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