Publication:
The roles of 68Ga-PSMA PET/CT and 18F-FDG PET/CT imaging in patients with triple-negative breast cancer and the association of tissue PSMA and claudin 1, 4, and 7 levels with PET findings

dc.contributor.coauthorArslan, E.
dc.contributor.coauthorErgul, N.
dc.contributor.coauthorBeyhan, E.
dc.contributor.coauthorErol, O.
dc.contributor.coauthorCin, M.
dc.contributor.coauthorHavare, S. Battal
dc.contributor.coauthorTrabulus, D. Can
dc.contributor.coauthorMermut, O.
dc.contributor.coauthorCermik, T. F.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorAkbaş, Sinem
dc.contributor.kuprofileDoctor
dc.contributor.yokidN/A
dc.date.accessioned2024-11-10T00:07:08Z
dc.date.issued2021
dc.description.abstractAim of study is to compare the results of Gallium68-prostate-specific membrane antigen (68Ga-PSMA) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography(PET)/computed tomography (CT), to evaluate the correlation between PET findings and the level of PSMA, Claudin (Clau) 1, 4, and 7 receptors obtained by immunohistochemical (IHC) analysis, and to determine potential predictive and prognostic values in TNBC. Methods Forty-seven lesions of 42 subjects diagnosed TNBC both underwent PET/CT scan for preoperative staging/restaging were prospectively included study. PSMA, Clau 1, 4, and 7 expressions were IHC evaluated from the biopsy samples of the primary tumor (PT). Maximum standardized uptake value(SUV max) of the PT, lymph node, and distant organ metastases (DOMs) on 18F-FDG and 68Ga-PSMA PET/CT were compared with PSMA, Clau 1, 4, and 7 receptor expressions. Results IHC analyses on 29 BC lesions to demonstrate Clau expression showed 86% (25/29) Clau 1, 86% (25/29) Clau 4, 45% (13/29) Clau 7, and 48% (14/29) PSMA-positive. The mean DOM (SUVmax) was 15.5±11.6 for 18F-FDG and 6.0±2.9 for 68Ga-PSMA. Axial diameter of BC PT had a significant positive correlation with 18F-FDG SUVmax, 68Ga-PSMA SUVmax, and PSMA scores. BC lesions 68Ga-PSMA SUVmax had a significant negative correlation with the Ki-67 index. Axial diameter of the primary tumor had significant negative correlation with Clau 7 scores (r=−0.409, P=0.034). Absence of Clau 1 expression found to significantly increase the rate of DOM (100% vs. 28%) (P=0.014). All patients with axillary lymph node (ALN) metastases (n=17, 100%) exhibited Clau 4 positivity (P=0.021). The presence of PSMA expression observed to significantly increase the rate of ALN metastases (64.7% vs. 25%) (P=0.035). Conclusion Confirming PSMA expression with PET imaging would be significant as PSMA, a theranostic agent, may be a considerable potential agent for radionuclide treatment strategies, in addition to its additional diagnostic contribution to FDG, especially in patients with metastatic TNBC, which is an aggressive, heterogeneous disease.
dc.description.indexedbyWoS
dc.description.issueSUPPL 1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume48
dc.identifier.doiN/A
dc.identifier.eissn1619-7089
dc.identifier.issn1619-7070
dc.identifier.urihttps://journals.lww.com/nuclearmedicinecomm/fulltext/2023/04000/the_roles_of_68ga_psma_pet_ct_and_18f_fdg_pet_ct.7.aspx
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16735
dc.keywordsClaudin 1
dc.keywordsClaudin 4
dc.keywordsClaudin 7
dc.keywords18F-fluorodeoxyglucose
dc.keywordsGallium-68-prostate-specific membrane antigen
dc.keywordsPET/computed tomography
dc.keywordsProstate-specific membrane antigen
dc.keywordsTriple-negative breast cancer
dc.languageEnglish
dc.publisherSpringer
dc.sourceEuropean Journal of Nuclear Medicine and Molecular Imaging
dc.subjectRadiology
dc.subjectNuclear medicine
dc.subjectMedical imaging
dc.titleThe roles of 68Ga-PSMA PET/CT and 18F-FDG PET/CT imaging in patients with triple-negative breast cancer and the association of tissue PSMA and claudin 1, 4, and 7 levels with PET findings
dc.typeMeeting Abstract
dspace.entity.typePublication
local.contributor.authoridN/A
local.contributor.kuauthorAkbaş, Sinem
local.publication.orgunit2KUH (Koç University Hospital)
relation.isOrgUnitOfPublicationf91d21f0-6b13-46ce-939a-db68e4c8d2ab
relation.isOrgUnitOfPublication.latestForDiscoveryf91d21f0-6b13-46ce-939a-db68e4c8d2ab

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