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The roles of 68Ga-PSMA PET/CT and 18F-FDG PET/CT imaging in patients with triple-negative breast cancer and the association of tissue PSMA and claudin 1, 4, and 7 levels with PET findings

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Arslan, E.
Ergul, N.
Beyhan, E.
Erol, O.
Cin, M.
Havare, S. Battal
Trabulus, D. Can
Mermut, O.
Cermik, T. F.

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Aim of study is to compare the results of Gallium68-prostate-specific membrane antigen (68Ga-PSMA) and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography(PET)/computed tomography (CT), to evaluate the correlation between PET findings and the level of PSMA, Claudin (Clau) 1, 4, and 7 receptors obtained by immunohistochemical (IHC) analysis, and to determine potential predictive and prognostic values in TNBC. Methods Forty-seven lesions of 42 subjects diagnosed TNBC both underwent PET/CT scan for preoperative staging/restaging were prospectively included study. PSMA, Clau 1, 4, and 7 expressions were IHC evaluated from the biopsy samples of the primary tumor (PT). Maximum standardized uptake value(SUV max) of the PT, lymph node, and distant organ metastases (DOMs) on 18F-FDG and 68Ga-PSMA PET/CT were compared with PSMA, Clau 1, 4, and 7 receptor expressions. Results IHC analyses on 29 BC lesions to demonstrate Clau expression showed 86% (25/29) Clau 1, 86% (25/29) Clau 4, 45% (13/29) Clau 7, and 48% (14/29) PSMA-positive. The mean DOM (SUVmax) was 15.5±11.6 for 18F-FDG and 6.0±2.9 for 68Ga-PSMA. Axial diameter of BC PT had a significant positive correlation with 18F-FDG SUVmax, 68Ga-PSMA SUVmax, and PSMA scores. BC lesions 68Ga-PSMA SUVmax had a significant negative correlation with the Ki-67 index. Axial diameter of the primary tumor had significant negative correlation with Clau 7 scores (r=−0.409, P=0.034). Absence of Clau 1 expression found to significantly increase the rate of DOM (100% vs. 28%) (P=0.014). All patients with axillary lymph node (ALN) metastases (n=17, 100%) exhibited Clau 4 positivity (P=0.021). The presence of PSMA expression observed to significantly increase the rate of ALN metastases (64.7% vs. 25%) (P=0.035). Conclusion Confirming PSMA expression with PET imaging would be significant as PSMA, a theranostic agent, may be a considerable potential agent for radionuclide treatment strategies, in addition to its additional diagnostic contribution to FDG, especially in patients with metastatic TNBC, which is an aggressive, heterogeneous disease.

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Springer

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Radiology, Nuclear medicine, Medical imaging

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European Journal of Nuclear Medicine and Molecular Imaging

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