Publication: Paper integrated microfluidic contact lens for colorimetric glucose detection
dc.contributor.coauthor | İstif, Emin | |
dc.contributor.department | Department of Mechanical Engineering | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.kuauthor | Abbasiasl, Taher | |
dc.contributor.kuauthor | Beker, Levent | |
dc.contributor.kuauthor | Das, Ritu | |
dc.contributor.kuauthor | İşgör, Pelin Kübra | |
dc.contributor.kuauthor | Yener, Umut Can | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.date.accessioned | 2024-12-29T09:39:47Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Contact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom processes and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. The paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within ∼10 s. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 μl. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 10 | |
dc.description.openaccess | Gold Open Access | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | TÜBİTAK | |
dc.description.volume | 3 | |
dc.identifier.doi | 10.1039/d4sd00135d | |
dc.identifier.eissn | 2635-0998 | |
dc.identifier.quartile | Q3 | |
dc.identifier.scopus | 2-s2.0-85203513336 | |
dc.identifier.uri | https://doi.org/10.1039/d4sd00135d | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/23103 | |
dc.identifier.wos | 1306377600001 | |
dc.keywords | Tear film | |
dc.keywords | Sensors | |
dc.keywords | People | |
dc.keywords | System | |
dc.language.iso | eng | |
dc.publisher | Royal Soc Chemistry | |
dc.relation.ispartof | Sensors and Diagnostics | |
dc.subject | Biological marker | |
dc.subject | Biosensor | |
dc.subject | Wearable sensor | |
dc.title | Paper integrated microfluidic contact lens for colorimetric glucose detection | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | İşgör, Pelin Kübra | |
local.contributor.kuauthor | Abbasiasl, Taher | |
local.contributor.kuauthor | Das, Ritu | |
local.contributor.kuauthor | Yener, Umut Can | |
local.contributor.kuauthor | Beker, Levent | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | Department of Mechanical Engineering | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
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relation.isOrgUnitOfPublication.latestForDiscovery | ba2836f3-206d-4724-918c-f598f0086a36 | |
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