Publication:
Paper integrated microfluidic contact lens for colorimetric glucose detection

dc.contributor.coauthorİstif, Emin
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorAbbasiasl, Taher
dc.contributor.kuauthorBeker, Levent
dc.contributor.kuauthorDas, Ritu
dc.contributor.kuauthorİşgör, Pelin Kübra
dc.contributor.kuauthorYener, Umut Can
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-12-29T09:39:47Z
dc.date.issued2024
dc.description.abstractContact lenses offer a simple, cost-effective, and non-invasive method for in situ real-time analysis of various biomarkers. Electro-chemical sensors are integrated into contact lenses for analysis of various biomarkers. However, they suffer from rigid electronic components and connections, leading to eye irritation and biomarker concentration deviation. Here, a flexible and microfluidic integrated paper-based contact lens for colorimetric analysis of glucose was implemented. Facilitating a three-dimensional (3D) printer for lens fabrication eliminates cumbersome cleanroom processes and provides a simple, batch compatible process. Due to the capillary force of the filter paper, the sample was routed to detection chambers inside microchannels, and it allowed further colorimetric detection. The paper-embedded microfluidic contact lens successfully detects glucose down to 2 mM within ∼10 s. The small dimension of the microfluidic system enables detection of glucose levels as low as 5 μl. The results show the potential of the presented approach to analyze glucose concentration in a rapid manner. It is demonstrated that the fabricated contact lens can successfully detect glucose levels of diabetic patients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessGold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.volume3
dc.identifier.doi10.1039/d4sd00135d
dc.identifier.eissn2635-0998
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85203513336
dc.identifier.urihttps://doi.org/10.1039/d4sd00135d
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23103
dc.identifier.wos1306377600001
dc.keywordsTear film
dc.keywordsSensors
dc.keywordsPeople
dc.keywordsSystem
dc.language.isoeng
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofSensors and Diagnostics
dc.subjectBiological marker
dc.subjectBiosensor
dc.subjectWearable sensor
dc.titlePaper integrated microfluidic contact lens for colorimetric glucose detection
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorİşgör, Pelin Kübra
local.contributor.kuauthorAbbasiasl, Taher
local.contributor.kuauthorDas, Ritu
local.contributor.kuauthorYener, Umut Can
local.contributor.kuauthorBeker, Levent
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Engineering
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2Graduate School of Sciences and Engineering
relation.isOrgUnitOfPublicationba2836f3-206d-4724-918c-f598f0086a36
relation.isOrgUnitOfPublication3fc31c89-e803-4eb1-af6b-6258bc42c3d8
relation.isOrgUnitOfPublication91bbe15d-017f-446b-b102-ce755523d939
relation.isOrgUnitOfPublication.latestForDiscoveryba2836f3-206d-4724-918c-f598f0086a36
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublication434c9663-2b11-4e66-9399-c863e2ebae43
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
IR04702.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format