Publication:
A primer on metabolic memory: why existing diabesity treatments fail

dc.contributor.coauthorRossing, Peter
dc.contributor.coauthorAfşar, Barış
dc.contributor.coauthorSağ, Alan A.
dc.contributor.coauthorSiriopol, Dimitrie
dc.contributor.coauthorKuwabara, Masanari
dc.contributor.coauthorOrtiz, Alberto
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇöpür, Sidar
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:45:36Z
dc.date.issued2021
dc.description.abstractDespite massive government and private sector investments into prevention of cardiovascular disease, diabetes mellitus and obesity, efforts have largely failed, and the burden of cost remains in the treatment of downstream morbidity and mortality, with overall stagnating outcomes. A new paradigm shift in the approach to these patients may explain why existing treatment strategies fail, and offer new treatment targets. This review aims to provide a clinician-centred primer on metabolic memory, defined as the sum of irreversible genetic, epigenetic, cellular and tissue-level alterations that occur with long-time exposure to metabolic derangements.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume14
dc.identifier.doi10.1093/ckj/sfaa143
dc.identifier.eissn2048-8513
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03325
dc.identifier.issn2048-8505
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85118106141
dc.identifier.urihttps://hdl.handle.net/20.500.14288/3633
dc.identifier.wos646249700005
dc.keywordsChronic kidney disease
dc.keywordsDiabetic kidney disease
dc.keywordsEpigenetics
dc.keywordsMetabolic memory
dc.keywordsSirtuin 1
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.grantnoNA
dc.relation.ispartofClinical Kidney Journal
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10114
dc.subjectUrology
dc.subjectNephrology
dc.titleA primer on metabolic memory: why existing diabesity treatments fail
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorÇöpür, Sidar
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
10114.pdf
Size:
698.3 KB
Format:
Adobe Portable Document Format