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Generation of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system

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dc.contributor.coauthorCanac, Robin
dc.contributor.coauthorCaillaud, Amandine
dc.contributor.coauthorCimarosti, Bastien
dc.contributor.coauthorGirardeau, Aurore
dc.contributor.coauthorHamamy, Hanan
dc.contributor.coauthorBonnard, Carine
dc.contributor.coauthorAl Sayed, Zeina R.
dc.contributor.coauthorDavid, Laurent
dc.contributor.coauthorPoschmann, Jeremie
dc.contributor.coauthorLemarchand, Patricia
dc.contributor.coauthorLamirault, Guillaume
dc.contributor.coauthorGaborit, Nathalie
dc.contributor.kuauthorReversade, Bruno
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.date.accessioned2024-11-09T12:27:07Z
dc.date.issued2022
dc.description.abstractStudies on animal models have shown that Irx5 is an important regulator of cardiac development and that it regulates ventricular electrical repolarization gradient in the adult heart. Mutations in IRX5 have also been linked in humans to cardiac conduction defects. In order to fully characterize the role of IRX5 during cardiac development and in cardiomyocyte function, we generated three genetically-modified human induced pluripotent stem cell lines: two knockout lines (heterozygous and homozygous) and a knockin HA-tagged line (homozygous).
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipFrench National Research Agency
dc.description.sponsorshipLa Fédération Française de Cardiologie
dc.description.sponsorshipFondation Lefoulon-Delalande
dc.description.sponsorshipMarie Curie Inter-national Incoming Fellowship FP7-PEOPLE-2012-IIF
dc.description.sponsorshipMarion Elizabeth Brancher (MEB)
dc.description.versionPublisher version
dc.description.volume58
dc.formatpdf
dc.identifier.doi10.1016/j.scr.2021.102627
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03384
dc.identifier.issn1873-5061
dc.identifier.linkhttps://doi.org/10.1016/j.scr.2021.102627
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85121303211
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1732
dc.identifier.wos789707100002
dc.keywordsHomeobox genes
dc.keywordsTranscription Factor
dc.keywordsLiver cell carcinoma
dc.languageEnglish
dc.publisherElsevier
dc.relation.grantnoHEART iPS ANR-15-CE14-0019-01
dc.relation.grantnoPIIF-GA-2012-331436
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10171
dc.sourceStem Cell Research
dc.subjectGenetics
dc.titleGeneration of three human induced pluripotent stem cell lines with IRX5 knockout and knockin genetic editions using CRISPR-Cas9 system
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorReversade, Bruno

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