Publication: CD3(-)CD56(+) NK cells display an inflammatory profile in RR-MS patients
Program
KU-Authors
KU Authors
Co-Authors
Tahrali, İlhan
Küçüksezer, Umut Can
Akdeniz, Nilgün
Uygunoğlu, Uğur
Aktaş-Çetin, Esin
Deniz, Günnur
Advisor
Publication Date
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Abstract
Multiple Sclerosis (MS) is an immune-mediated and neurodegenerative disease of central nervous system. Relapsing-remitting (RR)-MS occurring with acute attacks and remissions, is the most common clinical type of MS. There are different strategies applied in first-line treatment of RR-MS patients such as interferon-beta (IFN-beta) and glatiramer acetate. In this study, activating and inhibitory receptor expressions and interleukin (IL)-22 levels of NK cells were investigated in RR-MS patients with or without IFN-beta therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-beta therapy. Elevated NK cells with activating profile and increased IL-22 under IFN-beta therapy suggest that IFN-beta treatment might direct NK cells toward a pro-inflammatory status.
Description
Source:
Immunology Letters
Publisher:
Elsevier
Keywords:
Subject
Immunology