Publication: CD3(-)CD56(+) NK cells display an inflammatory profile in RR-MS patients
Program
KU-Authors
KU Authors
Co-Authors
Tahrali, İlhan
Küçüksezer, Umut Can
Akdeniz, Nilgün
Uygunoğlu, Uğur
Aktaş-Çetin, Esin
Deniz, Günnur
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Abstract
Multiple Sclerosis (MS) is an immune-mediated and neurodegenerative disease of central nervous system. Relapsing-remitting (RR)-MS occurring with acute attacks and remissions, is the most common clinical type of MS. There are different strategies applied in first-line treatment of RR-MS patients such as interferon-beta (IFN-beta) and glatiramer acetate. In this study, activating and inhibitory receptor expressions and interleukin (IL)-22 levels of NK cells were investigated in RR-MS patients with or without IFN-beta therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-beta therapy. Elevated NK cells with activating profile and increased IL-22 under IFN-beta therapy suggest that IFN-beta treatment might direct NK cells toward a pro-inflammatory status.
Source
Publisher
Elsevier
Subject
Immunology
Citation
Has Part
Source
Immunology Letters
Book Series Title
Edition
DOI
10.1016/j.imlet.2019.10.006