Publication:
CD3(-)CD56(+) NK cells display an inflammatory profile in RR-MS patients

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dc.contributor.coauthorTahrali, İlhan
dc.contributor.coauthorKüçüksezer, Umut Can
dc.contributor.coauthorAkdeniz, Nilgün
dc.contributor.coauthorUygunoğlu, Uğur
dc.contributor.coauthorAktaş-Çetin, Esin
dc.contributor.coauthorDeniz, Günnur
dc.contributor.kuauthorAltıntaş, Ayşe
dc.contributor.kuprofileFaculty Member
dc.contributor.schoolcollegeinstituteSchool of Medicine
dc.contributor.yokid11611
dc.date.accessioned2024-11-10T00:07:09Z
dc.date.issued2019
dc.description.abstractMultiple Sclerosis (MS) is an immune-mediated and neurodegenerative disease of central nervous system. Relapsing-remitting (RR)-MS occurring with acute attacks and remissions, is the most common clinical type of MS. There are different strategies applied in first-line treatment of RR-MS patients such as interferon-beta (IFN-beta) and glatiramer acetate. In this study, activating and inhibitory receptor expressions and interleukin (IL)-22 levels of NK cells were investigated in RR-MS patients with or without IFN-beta therapy. Activating receptor expression and IL-22 levels of NK cells were increased in RR-MS patients under IFN-beta therapy. Elevated NK cells with activating profile and increased IL-22 under IFN-beta therapy suggest that IFN-beta treatment might direct NK cells toward a pro-inflammatory status.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsorshipScientific Research Projects Coordination Unit (BAP) of Istanbul University, Turkey [18423]
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [112S005] We thank Erdem Tuzun, MD for critical reading of the manuscript. This study was funded by Scientific Research Projects Coordination Unit (BAP) of Istanbul University, Turkey (Project number: 18423) and The Scientific and Technological Research Council of Turkey (TUBITAK, Project number: 112S005).
dc.description.volume216
dc.identifier.doi10.1016/j.imlet.2019.10.006
dc.identifier.eissn1879-0542
dc.identifier.issn0165-2478
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85073454849
dc.identifier.urihttp://dx.doi.org/10.1016/j.imlet.2019.10.006
dc.identifier.urihttps://hdl.handle.net/20.500.14288/16739
dc.identifier.wos501639200009
dc.keywordsIL-22
dc.keywordsMultiple sclerosis
dc.keywordsNatural killer cells
dc.keywordsNKG2A
dc.keywordsNKG2D
dc.keywordsNKp44
dc.languageEnglish
dc.publisherElsevier
dc.sourceImmunology Letters
dc.subjectImmunology
dc.titleCD3(-)CD56(+) NK cells display an inflammatory profile in RR-MS patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.authorid0000-0002-8524-5087
local.contributor.kuauthorAltıntaş, Ayşe

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