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Comparison of oncological and surgical outcomes between formal pancreatic resections and parenchyma-sparing resections for small PanNETs (<2 cm): Pancreas2000 Research and Educational Program (Course 9) Study Protocol

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Pehlevan, Ɩzge SerƧe
Benzer, Derya
Karatekin, Güner
Ovalı, Hüsnü Fahri

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Pancreatic neuroendocrine tumors (PanNETs) are rare tumors but incidence is increasing. An increasing number of these tumors are diagnosed incidentally when they are small (<2 cm) and when patients are asymptomatic. The European Neuroendocrine Tumor Society (ENETS) recommends conservative watch and wait policy for these patients. However, best surgical approach (parenchyma-sparing or formal oncological resection) for these small tumors when surgery is indicated is currently unknown. Parenchyma-sparing resections such as enucleation is associated with higher risk of post-operative morbidity compared to formal oncological resections. They are also be associated with potentially inadequate surgical margin clearance and with lack of lymphadenectomy for full pathological staging. Method: this study is a retrospective study and the aim is to analyze pre-operative clinical predictors of nodal metastases for small PanNETs to identify which patients are at a lower risk of lymph node metastases and are therefore suitable for parenchyma-sparing resection. Conclusion: the primary endpoint of this study is to determine if pre-operative clinical predictors such as tumor size are associated with lymph node involvement in small PanNETs.

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Frontiers

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Medicine, General and internal medicine

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Frontiers in Medicine

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10.3389/fmed.2020.00559

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