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Comparison of oncological and surgical outcomes between formal pancreatic resections and parenchyma-sparing resections for small PanNETs (<2 cm): Pancreas2000 Research and Educational Program (Course 9) Study Protocol

dc.contributor.coauthorPehlevan, Özge Serçe
dc.contributor.coauthorBenzer, Derya
dc.contributor.coauthorKaratekin, Güner
dc.contributor.coauthorOvalı, Hüsnü Fahri
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorTuncer, Ceren
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T13:21:43Z
dc.date.issued2020
dc.description.abstractPancreatic neuroendocrine tumors (PanNETs) are rare tumors but incidence is increasing. An increasing number of these tumors are diagnosed incidentally when they are small (<2 cm) and when patients are asymptomatic. The European Neuroendocrine Tumor Society (ENETS) recommends conservative watch and wait policy for these patients. However, best surgical approach (parenchyma-sparing or formal oncological resection) for these small tumors when surgery is indicated is currently unknown. Parenchyma-sparing resections such as enucleation is associated with higher risk of post-operative morbidity compared to formal oncological resections. They are also be associated with potentially inadequate surgical margin clearance and with lack of lymphadenectomy for full pathological staging. Method: this study is a retrospective study and the aim is to analyze pre-operative clinical predictors of nodal metastases for small PanNETs to identify which patients are at a lower risk of lymph node metastases and are therefore suitable for parenchyma-sparing resection. Conclusion: the primary endpoint of this study is to determine if pre-operative clinical predictors such as tumor size are associated with lymph node involvement in small PanNETs.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume7
dc.identifier.doi10.3389/fmed.2020.00559
dc.identifier.eissn2296-858X
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR02430
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85091478460
dc.identifier.urihttps://doi.org/10.3389/fmed.2020.00559
dc.identifier.wos574611900001
dc.keywordsOncological outcomes
dc.keywordsPancreatic neurendocrine tumor
dc.keywordsPancreatic resection
dc.keywordsParenchyma sparing pancreatectomy
dc.keywordsSurvival
dc.language.isoeng
dc.publisherFrontiers
dc.relation.grantnoNA
dc.relation.ispartofFrontiers in Medicine
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/9067
dc.subjectMedicine
dc.subjectGeneral and internal medicine
dc.titleComparison of oncological and surgical outcomes between formal pancreatic resections and parenchyma-sparing resections for small PanNETs (<2 cm): Pancreas2000 Research and Educational Program (Course 9) Study Protocol
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTunçer, Ceren
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
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relation.isOrgUnitOfPublication.latestForDiscovery91bbe15d-017f-446b-b102-ce755523d939
relation.isParentOrgUnitOfPublicationd437580f-9309-4ecb-864a-4af58309d287
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