Publication:
Determination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery

dc.contributor.coauthorOzbas, Burak
dc.contributor.coauthorKeskin, Onur
dc.contributor.coauthorHecker, Hartmut
dc.contributor.coauthorKarahan, Irfan
dc.contributor.coauthorOzbas, Cansu
dc.contributor.coauthorKalkan, Cagdas
dc.contributor.coauthorKartal, Aysun
dc.contributor.coauthorOnder, Fatih Oguz
dc.contributor.coauthorOncu, Burcu Kahveci
dc.contributor.coauthorGunsar, Fulya
dc.contributor.coauthorIdilman, Ramazan
dc.contributor.coauthorWeissenborn, Karin
dc.contributor.coauthorOzutemiz, Omer
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAkyıldız, Murat
dc.contributor.kuauthorGençdal, Genco
dc.contributor.kuauthorYurtaydın, Süleyman Cihan
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:29:03Z
dc.date.issued2021
dc.description.abstractBackground Psychometric hepatic encephalopathy score (PHES) needs local standardization. Aims This study aimed at standardizing PHES for Turkish patients and compare them with German norms; to determine minimal hepatic encephalopathy (mHE) prevalence with two different methods [PHES battery and Critical Flicker Frequency (CFF)] and to assess whether sub-tests of the battery can be used for screening for mHE. Methods Healthy volunteers (n = 816; 400 male) and cirrhotics (n = 124; 58 male) were included. For mHE diagnosis PHES score threshold was set at <= - 5 points and that of CFF at < 39 Hz. For comparing German and Turkish norms, datasets were combined. Multiple backward procedure was applied to assess effects of age, sex and education on single tests of the battery. Receiver operating characteristic (ROC) curves were created for assessing diagnostic capabilities of subtests of the battery. Results PHES norms for Turks were developed. MHE prevalence in compensated cirrhotics was 29.8% and 27.4% with PHES and CFF tests, respectively, with low compatibility (kappa coefficient 0.389); mHE prevalence decreased to 16% when both tests were combined. Turks performed worse vs Germans in the digit symbol (DS) and serial dotting (SD) subtests but performed better in other subtests. In ROC analyzes of subtests, the combination of DS + SD tests achieved an AUROC of 0.974 versus PHES. Conclusions Use of two methods for diagnosing mHE is important for research purposes. From a clinical perspective, sensitivity with acceptable specificity may suffice for screening instruments for mHE. Combined use of DS and SD subtests of the PHES battery appears suitable for this purpose.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume15
dc.identifier.doi10.1007/s12072-021-10207-5
dc.identifier.eissn1936-0541
dc.identifier.issn1936-0533
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85107429570
dc.identifier.urihttps://doi.org/10.1007/s12072-021-10207-5
dc.identifier.urihttps://hdl.handle.net/20.500.14288/11978
dc.identifier.wos657562000001
dc.keywordsMinimal hepatic encephalopathy
dc.keywordsPortosystemic hepatic encephalopathy score
dc.keywordsCritical flicker frequency
dc.keywordsCirrhosis
dc.keywordsTurkish norms critical flicker frequency
dc.keywordsMR spectroscopy
dc.keywordsCirrhosis
dc.keywordsScore
dc.keywordsQuantification
dc.keywordsNormalization
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofHepatology International
dc.subjectGastroenterology
dc.subjectHepatology
dc.titleDetermination of Turkish norms of psychometric tests for diagnosing minimal hepatic encephalopathy and proposal of a high sensitive screening test battery
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGençdal, Genco
local.contributor.kuauthorAkyıldız, Murat
local.contributor.kuauthorYurtaydın, Süleyman Cihan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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