Publication: A small molecule identified through an in silico screen inhibits Aurora B–INCENP interaction
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Abstract
Aurora B is a serine/threonine kinase that has a central role in the regulation of mitosis. The observation of Aurora B overexpression in cancer makes it a promising target to develop antitumoral inhibitors. We describe a new potential inhibitor that exclusively targets the interaction site of Aurora B and its activator INCENP. We performed a structure-based virtual screening and determined five potential candidates of 200000 compounds, which selectively bind to the Aurora B
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Wiley
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Biochemistry, Molecular biology, Clinical chemistry, Pharmacology, Pharmacy
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Chemical Biology and Drug Design
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10.1111/cbdd.12816
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