Publication:
Rathke's cleft cysts: from pathophysiology to management

dc.contributor.coauthorDarko, Kwadwo
dc.contributor.coauthorDetchou, Donald
dc.contributor.coauthorBarrie, Umaru
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorAydın, Serhat
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-03-06T20:59:47Z
dc.date.issued2024
dc.description.abstractRathke's cleft cysts (RCCs) are benign, non-neoplastic lesions located in the sellar and suprasellar regions of the brain, originating from remnants of Rathke's pouch, an embryonic precursor to the anterior pituitary gland. Although RCCs are frequently asymptomatic and discovered incidentally during imaging studies, they can present with a variety of symptoms, including headaches, visual disturbances, and endocrine dysfunction due to the compression of adjacent neural structures. The management of RCCs is particularly challenging, as the decision to pursue conservative monitoring or surgical intervention depends heavily on the cyst's size, growth potential, and the severity of symptoms. Transsphenoidal surgery is the primary treatment for symptomatic RCCs, offering effective relief from symptoms through decompression of the cyst. However, recurrence remains a significant issue, with rates reported up to 33%, prompting debates about the extent of cyst wall removal during surgery. Recent advancements in minimally invasive endoscopic techniques have improved surgical outcomes, yet the risk of postoperative complications such as hypopituitarism and cerebrospinal fluid leaks persists. Additionally, stereotactic radiosurgery has emerged as a potential alternative for patients with recurrent RCCs or those who are not suitable candidates for repeat surgery. Despite its promise, the long-term safety and efficacy of radiotherapy in RCC management require further investigation. This narrative review aims to provide a comprehensive overview of RCCs, integrating the latest research and clinical guidelines to discuss pathophysiology, clinical presentation, and management strategies, emphasizing the need for a personalized approach to treating this complex condition.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.identifier.doi10.1007/s10143-024-02742-0
dc.identifier.eissn1437-2320
dc.identifier.issn0344-5607
dc.identifier.issue1
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85203008537
dc.identifier.urihttps://doi.org/10.1007/s10143-024-02742-0
dc.identifier.urihttps://hdl.handle.net/20.500.14288/27771
dc.identifier.volume47
dc.identifier.wos1304086700004
dc.keywordsRathke's cysts
dc.keywordsTransphenoidal surgery
dc.keywordsSellar cysts
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofNeurosurgical Review
dc.subjectClinical neurology
dc.subjectSurgery
dc.titleRathke's cleft cysts: from pathophysiology to management
dc.typeLetter
dspace.entity.typePublication
local.contributor.kuauthorAydın, Serhat
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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