Publication: Differences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States
Program
KU-Authors
KU Authors
Co-Authors
Cano Garcia, Cristina
Nimer, Nancy
Piccinelli, Mattia Luca
Tappero, Stefano
Panunzio, Andrea
Barletta, Francesco
Incesu, Reha-Baris
Tian, Zhe
Saad, Fred
Kapoor, Anil
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Abstract
Purpose: To quantify differences in five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age- and sex-matched population-based controls, especially when race/ethnicity is considered. Methods: We relied on the Surveillance, Epidemiology and End Results database (2006–2016) to identify newly diagnosed (2006- 2011) ccmRCC patients of either Caucasian, Hispanic, African American, or Asian/Pacific Islander race/ethnicity. For each case, we simulated an age- and sex-matched control (Monte Carlo simulation), relying on Social Security Administration Life Tables with five-year follow-up. We compared OS between ccmRCC patients and controls. Multivariable Cox regression models tested for race/ethnicity effect on OS. Results: Of 3067 ccmRCC patients, 2167 (71%) were Caucasians vs. 488 (16%) Hispanics vs. 216 (7%) African Americans and 196 (6%) Asians/Pacific Islanders. At five years, OS difference between ccmRCC patients vs. population-based controls was greatest in African Americans (11 vs. 94%, Δ = 84%), followed by Hispanics (16 vs. 94%, Δ = 77%), Caucasians (16 vs. 89%, Δ = 73%) and Asians/Pacific Islanders (19 vs. 88%, Δ = 70%). In multivariable Cox regression models, African Americans exhibited highest Hazard Ratio for death (HR 1.3, p= 0.003). Conclusion: Relative to Life Tables’ derived age- and sex-matched controls, ccmRCC patients exhibit drastically worse OS, especially African Americans.
Source
Publisher
Elsevier Inc.
Subject
Kidneys, Metastasis, Cancer
Citation
Has Part
Source
Annals of Epidemiology
Book Series Title
Edition
DOI
10.1016/j.annepidem.2023.01.003