Publication:
Differences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States

dc.contributor.coauthorCano Garcia, Cristina
dc.contributor.coauthorNimer, Nancy
dc.contributor.coauthorPiccinelli, Mattia Luca
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorPanunzio, Andrea
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorKapoor, Anil
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorAntonelli, Alessandro
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorKluth, Luis A.
dc.contributor.coauthorBecker, Andreas
dc.contributor.coauthorChun, Felix K.H.
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:43:28Z
dc.date.issued2023
dc.description.abstractPurpose: To quantify differences in five-year overall survival (OS) between clear cell metastatic renal cell carcinoma (ccmRCC) patients and age- and sex-matched population-based controls, especially when race/ethnicity is considered. Methods: We relied on the Surveillance, Epidemiology and End Results database (2006–2016) to identify newly diagnosed (2006- 2011) ccmRCC patients of either Caucasian, Hispanic, African American, or Asian/Pacific Islander race/ethnicity. For each case, we simulated an age- and sex-matched control (Monte Carlo simulation), relying on Social Security Administration Life Tables with five-year follow-up. We compared OS between ccmRCC patients and controls. Multivariable Cox regression models tested for race/ethnicity effect on OS. Results: Of 3067 ccmRCC patients, 2167 (71%) were Caucasians vs. 488 (16%) Hispanics vs. 216 (7%) African Americans and 196 (6%) Asians/Pacific Islanders. At five years, OS difference between ccmRCC patients vs. population-based controls was greatest in African Americans (11 vs. 94%, Δ = 84%), followed by Hispanics (16 vs. 94%, Δ = 77%), Caucasians (16 vs. 89%, Δ = 73%) and Asians/Pacific Islanders (19 vs. 88%, Δ = 70%). In multivariable Cox regression models, African Americans exhibited highest Hazard Ratio for death (HR 1.3, p= 0.003). Conclusion: Relative to Life Tables’ derived age- and sex-matched controls, ccmRCC patients exhibit drastically worse OS, especially African Americans.
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.indexedbyWOS
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume79
dc.identifier.doi10.1016/j.annepidem.2023.01.003
dc.identifier.issn1047-2797
dc.identifier.scopus2-s2.0-85146852640
dc.identifier.urihttps://doi.org/10.1016/j.annepidem.2023.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.14288/13479
dc.identifier.wos991675700001
dc.keywordsEthnicity
dc.keywordsLife tables
dc.keywordsMetastatic renal cell carcinoma
dc.keywordsRace
dc.keywordsSEER
dc.keywordsSocial security administration
dc.keywordsCarcinoma, Renal cell
dc.keywordsEthnicity
dc.keywordsHumans
dc.keywordsKidney neoplasms
dc.keywordsSEER program
dc.keywordsUnited States
dc.keywordsCancer registry
dc.keywordsEpidemiology
dc.keywordsEthnicity
dc.keywordsHuman
dc.keywordsKidney tumor
dc.keywordsPathology
dc.keywordsRenal cell carcinoma
dc.keywordsUnited States
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofAnnals of Epidemiology
dc.subjectKidneys
dc.subjectMetastasis
dc.subjectCancer
dc.titleDifferences in overall survival between clear cell metastatic renal cell carcinoma patients versus population-based controls according to race/ethnicity in the United States
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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